{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:06:43Z","timestamp":1778825203236,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The majority of patients with nonischemic cardiomyopathy (NICM) present a perivalvular substrate that is either predominantly antero\u2010septal (AS) or infero\u2010lateral (IL), corresponding to specific ventricular tachycardia (VT) morphologies. The relative timing of far\u2010field and near\u2010field ventricular electrograms (EGMs) from stored implantable cardioverter\u2010defibrillator (ICD) events of VT may be used to distinguish AS from IL VT in NICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We analyzed 48 patients with NICM with either a primarily AS (54%) or IL (56%) VT source undergoing catheter ablation between 2003 and 2018. Only patients with retrievable ICD\u2010EGMs of spontaneous VT events which could be matched with VTs induced during the ablation procedure were included. A total of 56 VT events (52% AS origin and 48% IL origin) were analyzed, yielding a mean far\u2010field to near\u2010field interval of 31\u2009\u00b1\u200913\u2009milliseconds for AS VTs and 47\u2009\u00b1\u200919\u2009milliseconds for IL VTs (<jats:italic>P<\/jats:italic>\u2009=\u2009.001). At receiver operating characteristic analysis (AUC\u2009=\u20090.734), a far\u2010field to near\u2010field interval of\u2009\u2265\u200960\u2009milliseconds ruled out AS VTs in 29 (100%) cases and diagnosed IL VTs with a positive predictive value (PPV) of 100% and a negative predictive value (NPV) of 63%. An interval of\u2009\u2264\u200920\u2009milliseconds ruled out IL VTs in 25 (93%) cases and diagnosed AS VTs with a PPV of 83% and NPV of 57%. Significant overlap between the two groups was observed among far\u2010field to near\u2010field intervals in between 20\u2009milliseconds and 60\u2009milliseconds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relative timing of far\u2010field and near\u2010field EGMs from stored clinical ICD events of VT can be helpful to differentiate AS vs IL origin of VT in NICM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14135","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:12:21Z","timestamp":1566389541000},"page":"2334-2343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ventricular tachycardia in nonischemic cardiomyopathy: Anteroseptal vs inferolateral origin based on ICD ventricular electrogram timing"],"prefix":"10.1111","volume":"30","author":[{"given":"Santhisri","family":"Kodali","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Muser","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis 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