{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:47Z","timestamp":1740137147525,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["PIPE no.98\/08172\u20103"],"award-info":[{"award-number":["PIPE no.98\/08172\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Variability of ventricular arrhythmias among days in patients with Chagas disease is not detected by 24\u2009hours of Holter monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze whether ventricular arrhythmias are a random phenomenon or have a reproducible behavior in patients with Chagas cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Holter monitoring was recorded in 16 subjects with a mean age of 52\u2009\u00b1\u20098 years. They were clinically stable and had ventricular couplets, isolated premature ventricular contractions (PVCs), and nonsustained ventricular tachycardia (NSVT). The recordings occurred for 7 days. Hurst exponent (HE) evaluated randomness and predictability index (PI) and repeated analysis of variance (ANOVA) assessed reproducibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HE was significantly greater than 0.5 in all 16 patients, which confirms the nonrandomness of arrhythmias in this Chagas sample. The PI for ventricular couplets and isolated PVCs was, on average, 38% and 54%, respectively. ANOVA with repeated measurement showed significant differences in the daily frequency of ventricular couplets (n\u2009=\u200915, <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.05), isolated PVC (n\u2009=\u200912, <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.05), and NSVT (n\u2009=\u20097, <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ventricular arrhythmias in Chagas cardiomyopathy are not random. Dissimilarities in arrhythmias frequency make unlikely that 24\u2009hours of Holter recording can capture this variability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14162","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T04:40:52Z","timestamp":1568176852000},"page":"2370-2376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ventricular arrhythmias in the Chagas disease are not random phenomena: Long\u2010term monitoring in Chagas arrhythmias"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-3985","authenticated-orcid":false,"given":"Nancy Christiane","family":"Ferreira Silva","sequence":"first","affiliation":[{"name":"Department of Cardiology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui M. dos S.","family":"P\u00f3voa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo A. 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