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With the expanding role of VT ablation in patients with significant comorbidity, the choice between the RA and transseptal access routes is an increasingly important consideration. An individualized decision based on the location of the arrhythmogenic substrate, vascular anatomy, aortic valve morphology, and operator experience is necessary when deciding on the optimal access route. Among patients with challenging vascular anatomy, growing experience from structural interventions such as transcatheter aortic valve replacements and peripheral vascular interventions has provided valuable insights into techniques for safe retrograde access. The present review focuses on patient selection for RA access, potential complications associated with the technique, and optimal approaches for access in patients with challenging vascular or aortic valve anatomy.<\/jats:p>","DOI":"10.1111\/jce.14163","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T04:11:01Z","timestamp":1568088661000},"page":"2629-2639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retrograde aortic access during ventricular tachycardia ablation: Indications, techniques, and challenges"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3661-2776","authenticated-orcid":false,"given":"Ahmed M.","family":"Adlan","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology Liverpool Heart and Chest Hospital Liverpool United 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