{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:03:55Z","timestamp":1784603035729,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST106\u20102314\u2010B\u2010075\u2010073\u2010MY3"],"award-info":[{"award-number":["MOST106\u20102314\u2010B\u2010075\u2010073\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST107\u20102314\u2010B\u2010010 to 057"],"award-info":[{"award-number":["MOST107\u20102314\u2010B\u2010010 to 057"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST107\u20102314\u2010B\u2010075\u2010065\u2010MY3"],"award-info":[{"award-number":["MOST107\u20102314\u2010B\u2010075\u2010065\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial\/ventricular electrophysiology, and AF inducibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen rabbits were randomized into three groups: acid reflux (group 1, <jats:italic>n<\/jats:italic>\u2009=\u20096), control (group 2, <jats:italic>n<\/jats:italic>\u2009=\u20096), and acid reflux with periesophageal vagal blockade (group 3, <jats:italic>n<\/jats:italic>\u2009=\u20096). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5\u2009hours after the experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF\u2014making it highly likely that autonomic activity is important in mediating this effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14181","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:31:15Z","timestamp":1568349075000},"page":"2262-2270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-0843","authenticated-orcid":false,"given":"Ting\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-227X","authenticated-orcid":false,"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine and Cardiovascular Research National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-3926","authenticated-orcid":false,"given":"Shinya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Cardiovascular Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hui","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Lun","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine and Cardiovascular Research 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