{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:39:03Z","timestamp":1782254343615,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000592","name":"US-UK Fulbright Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS\u2010551761"],"award-info":[{"award-number":["SLS\u2010551761"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Long QT syndrome (LQTS) mutation carriers have elevated the risk of cardiac events even in the absence of QTc prolongation; however, mutation penetrance in patients with normal QTc may be reflected in abnormal T\u2010wave shape, particularly in KCNH2 mutation carriers. We aimed to assess whether the magnitude of a three\u2010dimensional T\u2010wave vector (TwVM) will identify KCNH2\u2010mutation carriers with normal QTc at risk for cardiac events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult LQT2 patients with QTc\u2009&lt;\u2009460 ms in men and &lt;470\u2009ms in women (n\u2009=\u2009113, age 42\u2009\u00b1\u200916 years, 43% male) were compared with genotype\u2010negative family members (n\u2009=\u20091007). The TwVM was calculated using T\u2010wave amplitudes in leads V6, II, and V2 as the square root of (TV6<jats:sup>2<\/jats:sup>\u2009+\u2009TII<jats:sup>2<\/jats:sup>\u2009+\u2009(0.5*TV2)<jats:sup>2<\/jats:sup>). Cox regression analysis adjusted for gender and time\u2010dependent beta\u2010blocker use was performed to assess cardiac event (CE) risk, defined as syncope, aborted cardiac arrest, implantable cardioverter\u2010defibrillator therapy, or sudden death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dichotomized by median of 0.30\u2009mV, lower TwVM was associated with elevated CE risk compared to those with high TwVM (HR\u2009=\u20092.95, 95% CI, 1.25\u20106.98, <jats:italic>P<\/jats:italic>\u2009=\u2009.014) and also remained significant after including sex and time\u2010dependent beta\u2010blocker usage in the Cox regression analysis (HR\u2009=\u20092.64, 95% CI, 1.64\u20104.24, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). However, these associations were found only in women but not in men who had low event rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T\u2010wave morphology quantified as repolarization vector magnitude using T\u2010wave amplitudes retrieved from standard 12\u2010lead electrocardiogram predicts cardiac events risk in LQT2 women and appears useful for risk stratification of KCNH2\u2010mutation carriers without QTc prolongation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14210","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T12:13:47Z","timestamp":1570104827000},"page":"2907-2913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative T\u2010wave morphology assessment from surface ECG is linked with cardiac events risk in genotype\u2010positive KCNH2 mutation carriers with normal QTc 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York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronislava","family":"Polonsky","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer Z.","family":"Rosero","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyotr G.","family":"Platonov","sequence":"additional","affiliation":[{"name":"Clinical Sciences Cardiology, Lund University  Lund 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