{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:55:31Z","timestamp":1774328131331,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage closure (LAAC) with LARIAT has emerged as one of the alternatives to oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (AF). Our aim was to study long\u2010term outcomes in patients undergoing LARIAT procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed patients screened for LARIAT device in four centers between December 2009 and June 2012. Out of these, patients who didn't undergo LAAC with the LARIAT device due to unfavorable LAA morphology and other preprocedural contraindications were included in control group. We analyzed thromboembolism, bleeding events, and mortality between LAA and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 153 patients were screened. Out of these, 108 (70.6%) patients underwent LARIAT placement (LAA arm) and 45 (29.4%) excluded patients were included in control arm. There were no differences in CHADS<jats:sub>2<\/jats:sub> and CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score. Mean HAS\u2010BLED score was significantly higher in the LARIAT group (3.5\u2009\u00b1\u20091.06 vs 3.09\u2009\u00b1\u20091.22, <jats:italic>P<\/jats:italic>\u2009=\u2009.04). Mean follow\u2010up time (in years) was 6.56\u2009\u00b1\u20090.84 in LAA and 6.5\u2009\u00b1\u20091.26 in control arm. During follow\u2010up period, the LARIAT group was associated with significantly less thromboembolic events (1.9% vs 24%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), bleeding events (9.2% vs 24.4%, <jats:italic>P<\/jats:italic>\u2009=\u2009.03), and mortality (5.6% vs 20%, <jats:italic>P<\/jats:italic>\u2009=\u2009.01) as compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term data from routine clinical practice from our study suggests that LAA exclusion with LARIAT device is an effective treatment in management of nonvalvular AF patients with high risk of stroke, bleeding, and mortality. Further randomized trials, such as aMAZE, will provide more insight in this expanding field.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14229","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T12:04:33Z","timestamp":1570622673000},"page":"2849-2857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term clinical outcomes from real\u2010world experience of left atrial appendage exclusion with LARIAT device"],"prefix":"10.1111","volume":"30","author":[{"given":"Valay","family":"Parikh","sequence":"first","affiliation":[{"name":"Department of Electrophysiology Baptist Health System  San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Bartus","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslaw","family":"Litwinowicz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit K.","family":"Turagam","sequence":"additional","affiliation":[{"name":"Section of Electrophysiology Icahn School of Medicine at Mount Sinai  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boguslaw","family":"Kapelak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Bartus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Podolec","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical University of Gdansk  Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Musat","sequence":"additional","affiliation":[{"name":"Section of Electrophysiology Valley Health System  Ridgewood New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdi","family":"Rasekh","sequence":"additional","affiliation":[{"name":"Section of Electrophysiology Texas Heart Institute  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-7254","authenticated-orcid":false,"given":"Suneet","family":"Mittal","sequence":"additional","affiliation":[{"name":"Section of Electrophysiology Valley Health System  Ridgewood New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Section of Electrophysiology, Baylor Medical Center University of Texas  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitish","family":"Badhwar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiac Electrophysiology University of California San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiac Electrophysiology University of California San Francisco  San Francisco California"},{"name":"Cardiovascular Research Institute, Institute for Regeneration Medicine University of California San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-2693","authenticated-orcid":false,"given":"Dhanunjaya","family":"Lakkireddy","sequence":"additional","affiliation":[{"name":"The Kansas City Heart Rhythm Institute &amp; 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