{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:50Z","timestamp":1740137150842,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The significance of the inducibility of atrial fibrillation (AF) after pulmonary vein isolation (PVI) in patients with AF remains disputable and polarizing. Therefore, we investigated the prognostic value of the inducibility of AF on long\u2010term outcome after PVI in patients without low\u2010voltage left atrial (LA) substrate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred forty\u2010five patients (mean age 59+\/\u22129years, 72% male) without LA low\u2010voltage areas (defined as electrogram amplitudes &lt;0.5\u2009mV) undergoing first PVI procedure were included in the study. Following successful PVI, inducibility was assessed by burst pacing from coronary sinus with a cycle length (CL) of 300, 250, and 200\u2009ms or the shortest CL resulting in 1:1 atrial capture. During the follow\u2010up period of up to 3 years, the rhythm outcome was monitored by serial 7\u2010days Holter electrocardiogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AF was induced in 38 patients (16%). Atypical atrial flutter was observed in six patients (2%), while typical flutter in three cases (1%).<\/jats:p><jats:p>Within the first 3 months, early recurrence was diagnosed in 39 patients (16%), while late recurrence was detected in 58 patients (24%) after a mean AF free survival of 28\u2009\u00b1\u20091 months.<\/jats:p><jats:p>While there was no impact on early recurrence, AF inducibility affected long\u2010term recurrence (31\u2009\u00b1\u20091 vs 23\u2009\u00b1\u20093 months; <jats:italic>P<\/jats:italic>\u2009=\u2009.001). In multivariate analysis, AF inducibility (hazard ratio [HR] 2.14; 95% confidence interval [CI], 1.03\u20104.45; <jats:italic>P<\/jats:italic>\u2009=\u2009.041) and persistent type of AF (HR 2.17; 95%CI, 1.06\u20134.47; <jats:italic>P<\/jats:italic>\u2009=\u2009.034) were associated with late AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients without low\u2010voltage substrate undergoing PVI, AF inducibility is a significant predictor of long\u2010term outcome. The pathomechanisms of this phenomenon must be further studied to be addressed by additional treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14234","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T14:10:37Z","timestamp":1571407837000},"page":"2768-2772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Significance of inducibility of atrial fibrillation after pulmonary vein isolation in patients with healthy left atrium substrate"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-1372","authenticated-orcid":false,"given":"Jedrzej","family":"Kosiuk","sequence":"first","affiliation":[{"name":"Department of Rhythmology Helios Clinic Koethen Koethen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Gr\u00fcndig","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav","family":"Dinov","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fcssigbrodt","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.11.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.06.032"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"54","article-title":"Non\u2010inducibility or termination as endpoints of atrial fibrillation ablation: what is their role?","volume":"7","author":"Baker M","year":"2014","journal-title":"Journal of Atrial 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