{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:47:36Z","timestamp":1791802056436,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T00:00:00Z","timestamp":1573344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Ablation of atrial vagal ganglia has been associated with improved pulmonary vein isolation (PVI) outcomes. Disruption of vagal reflexes results in heart rate (HR) increase. We investigated the association between HR change after PVI and freedom from atrial fibrillation (AF) at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients who underwent PVI for paroxysmal AF were identified from the Johns Hopkins Hospital AF registry. Electrocardiograms taken pre\u2010PVI and post\u2010PVI were used to determine the change in HR. Patients followed\u2010up at 3, 6, and 12 months. Of 257 patients (66% male, age 59+\/\u201011 years), 134 (52%) remained free from AF at 1 year. The average HR increased from 60.6\u2009\u00b1\u200911.3 beats per minute (bpm) pre\u2010PVI to 70.7\u2009\u00b1\u200912.0 bpm post\u2010PVI. Patients with recurrence of AF had lower post\u2010PVI HR than those who remained free from AF (67.8\u2009\u00b1\u20090.2 vs 73.3\u2009\u00b1\u200913.0 bpm; <jats:italic>P<\/jats:italic>\u2009&lt;.001). The probability of AF recurrence at 1\u2010year decreased as the change in HR increased (estimated odds ratio [OR], 0.83; 95% confidence interval [CI, 0.74\u20100.93]; <jats:italic>P<\/jats:italic>\u2009=\u2009.002). HR increase more than 15\u2009bpm was associated with the lowest odds of AF recurrence (estimated OR, 0.39; 95% [0.17\u20100.85]; <jats:italic>P<\/jats:italic>\u2009=\u2009.018) compared to HR decrease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resting HR was found to increase after PVI. Increase in HR more than 15\u2009bpm has a positive association with remaining free from atrial fibrillation at 1 year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14257","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T12:02:16Z","timestamp":1572523336000},"page":"2818-2822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Heart rate increase after pulmonary vein isolation predicts freedom from atrial fibrillation at 1 year"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-4443","authenticated-orcid":false,"given":"Zackary D.","family":"Goff","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balint","family":"Laczay","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins Hospital 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