{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:59:39Z","timestamp":1778817579492,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Totally thoracoscopic ablation for symptomatic atrial fibrillation (AF) refractory to drug or catheter based therapy is indicated as a Class 2A recommendation according to latest guidelines. Evidence for long\u2010term rhythm control and stroke reduction is limited. The aim of this study was to report on long\u2010term outcome after totally thoracoscopic ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In total 82 consecutive patients were included that underwent totally thoracoscopic ablation including left appendage closure (2012\u20102013). The primary outcome was freedom from atrial arrhythmia recurrence. Secondary outcomes were survival, freedom from cerebrovascular events, freedom from reablation and definite pacemaker implantation. The mean age was 59.9\u2009\u00b1\u20098.6 years and 71% were male. The mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score was 1.2\u2009\u00b1\u20091.0. The overall freedom from atrial arrhythmia was 60% after a mean follow up of 4.0\u2009\u00b1\u20090.6 years. Freedom from cerebrovascular events was 98.8% after mean follow\u2010up of 4.4\u2009\u00b1\u20090.3 years and overall survival was 98.8%, with one noncardiac related death. The observed rate of ischemic stroke, hemorrhagic stroke or transient ischemic attack was 0.3 per 100 patient\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Totally thoracoscopic ablation is an effective sustainable rhythm control therapy for AF with a reasonable recurrence rate and low stroke rate when performed in dedicated AF centers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14267","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T04:30:54Z","timestamp":1573014654000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term outcome after totally thoracoscopic ablation for atrial fibrillation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5159-6973","authenticated-orcid":false,"given":"Lara M.","family":"Vos","sequence":"first","affiliation":[{"name":"Department of 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