{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:21:39Z","timestamp":1790720499397,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["FKZ 81Z4710141"],"award-info":[{"award-number":["FKZ 81Z4710141"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81X2710149"],"award-info":[{"award-number":["81X2710149"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Catheter contact and local tissue characteristics are relevant information for successful radiofrequency current (RFC)\u2010ablation. Local impedance (LI) has been shown to reflect tissue characteristics and lesion formation during RFC\u2010ablation. Using a novel ablation catheter incorporating three mini\u2010electrodes, we investigated LI in relation to generator impedance (GI) in patients with ventricular tachycardia (VT) and its applicability as an indicator of effective RFC\u2010ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Baseline impedance, \u0394impedance during ablation and drop rate (\u0394impedance\/time) were analyzed for 625 RFC\u2010applications in 28 patients with recurrent VT undergoing RFC\u2010ablation. LI was lower in scarred (87.0\u2009\u03a9 [79.0\u201095.0]) compared to healthy myocardium (97.5\u2009\u03a9 ([82.75\u2010111.50]; <jats:italic>P<\/jats:italic>\u2009=\u2009.03) while GI did not differ between scarred and healthy myocardium. \u0394LI was higher (18\u2009\u03a9 [9.4\u201026.0]) for VT\u2010terminating as compared to non\u2010terminating RFC\u2010ablation (\u0394LI 13\u2009\u03a9 [8.85\u201018.0]; <jats:italic>P<\/jats:italic>\u2009=\u2009.03), but did not differ for \u0394GI between terminating vs nonterminating RFC\u2010ablation. Correspondingly, LI drop rate was higher for RFC\u2010ablation terminating the VT compared with RFC\u2010ablation not terminating the VT (0.63\u2009\u03a9\/s [0.52\u20100.76] vs 0.32\u2009\u03a9 [0.20\u20100.58]; <jats:italic>P<\/jats:italic>\u2009=\u2009.008) while there was no difference for GI drop rate. \u0394LI was higher in patients with nonischemic cardiomyopathy vs patients with ischemic cardiomyopathy (16\u2009\u03a9 [11.0\u201020.0] vs 11.0\u2009\u03a9 [7.85\u201017.00]; <jats:italic>P<\/jats:italic>\u2009=\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that LI is a sensitive parameter to guide RFC\u2010ablation in patients with VT. LI indicates differences in tissue characteristics and generally is higher in patients with nonischemic cardiomyopathy. Hence, the etiology of the underlying cardiomyopathy needs to be considered when adopting LI for monitoring catheter ablation of VT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14269","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T04:17:40Z","timestamp":1573186660000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Local impedance guides catheter ablation in patients with ventricular tachycardia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-0012","authenticated-orcid":false,"given":"Paula","family":"M\u00fcnkler","sequence":"first","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Gunawardene","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"Department of Cardiology Asklepios Hospital St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Jungen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Klatt","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana M.","family":"Schwarzl","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruken \u00d6.","family":"Akbulak","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Dinshaw","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"Department of Cardiology Asklepios Hospital St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Jularic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"Department of Cardiology Asklepios Hospital St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kathrin","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Riedel","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Merbold","sequence":"additional","affiliation":[{"name":"Boston Scientific Marlborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-9688","authenticated-orcid":false,"given":"Christian","family":"Eickholt","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"Department of Cardiology Asklepios Hospital St. Georg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"Department of Cardiology Asklepios Hospital St. Georg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb02897.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-015-0002-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.1.199"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01929.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.9.6.1280"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2005.05.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026586119600"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01552.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005831"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13654"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy273"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13270"},{"issue":"5","key":"e_1_2_9_14_1","first-page":"S32","article-title":"Voltage threshold for high density mapping catheter with short interspaced small electrodes","volume":"13","author":"Sacher F","year":"2016","journal-title":"Heart Rhythm [Abstract]"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.01.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006569"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.03.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12565"},{"key":"e_1_2_9_19_1","unstructured":"A Language and Environment for Statistical Computing R Core Team Vienna Austria 2018 https:\/\/www.R\u2010project.org"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.16.1744"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.16.1744"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.11.031"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004448"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.01.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.10.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0361"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13281"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.14269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:01:44Z","timestamp":1694116904000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/jce.14269"],"URL":"https:\/\/doi.org\/10.1111\/jce.14269","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"2019-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}