{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:55Z","timestamp":1791946135889,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data are available regarding the demographics, disease associations, and long\u2010term prognosis of patients with inappropriate sinus tachycardia (IST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish epidemiologic data for patients with IST, including symptom onset, comorbid disease, and long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed all patients with an IST diagnosis at the Mayo Clinic (Rochester, MN) during a 20\u2010year period (1998\u20102018). We extracted demographic data and clinical outcomes compared to an age and gender\u2010matched control group with atrioventricular nodal reentry tachycardia (AVNRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the study period, a total of 305 patients with IST were identified (mean follow\u2010up 3.5 years) with 92.1% female and mean age 33.2\u2009\u00b1\u200911.2 years. The most frequently identified circumstances triggering the condition included pregnancy (7.9%) and infectious illness (5.9%) while the most common comorbid conditions were depression (25.6%) and anxiety (24.6%). At diagnosis, the mean left ventricular ejection fraction (LVEF) was 62.3\u2009\u00b1\u20096.2%, with 77 patients having follow\u2010up echocardiographic data. No significant difference in LVEF was seen after a mean 4.9\u2009\u00b1\u20094.3\u2010year follow\u2010up (baseline LVEF 59.8\u2009\u00b1\u200910.7% vs subsequent 61.4\u2009\u00b1\u20098.1%; <jats:italic>P<\/jats:italic>\u2009=\u2009.2971). Two deaths occurred within the study period, with one related to myocardial infarction and the other noncardiac; compared to an age and gender\u2010matched AVNRT control group there was no excess mortality during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study cohort, IST predominately affects young females with structurally normal hearts and modest coexistent psychiatric disease. In most cases of IST, a major event occurring just before or at the time of diagnosis could not be identified, although nearly 8% of patients first noted symptoms during or shortly after pregnancy. In our cohort, there was no evidence of cardiomyopathy or mortality related to IST.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14288","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T04:29:27Z","timestamp":1574310567000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Natural history and clinical outcomes of inappropriate sinus tachycardia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-365X","authenticated-orcid":false,"given":"Samuel A.","family":"Shabtaie","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chance M.","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-5536","authenticated-orcid":false,"given":"Samuel J.","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2004.12.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542-474X.2003.08208.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy128"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X13666171129183826"},{"issue":"4","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/europace\/euw444","article-title":"European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia\u2010Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE)","volume":"19","author":"Katritsis DG","year":"2017","journal-title":"Europace"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02414.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9964-1"},{"issue":"3","key":"e_1_2_8_9_1","first-page":"212","article-title":"Inappropriate sinus tachycardia\u2010induced cardiomyopathy during pregnancy and successful treatment with ivabradine","volume":"16","author":"Sag S","year":"2016","journal-title":"Anatol J Cardiol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.04.035"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.05.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.856"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029"},{"key":"e_1_2_8_14_1","article-title":"Inappropriate sinus tachycardia in pregnancy: a benign phenomena?","volume":"2017","author":"Belham M","year":"2017","journal-title":"BMJ Case Rep"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2017.06.285"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834f0b1c"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00738-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90497-X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098253"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00034.2013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb02286.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000700"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.873"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61027-6"},{"key":"e_1_2_8_26_1","first-page":"S116","article-title":"Innapropriate sinus tachycardia\u2014cardiac syndrome or anxiety\u2010related disorder?","volume":"33","author":"Ramus P","year":"2016","journal-title":"Eur. 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