{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:32:36Z","timestamp":1791174756360,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GA17\u201013830S"],"award-info":[{"award-number":["GA17\u201013830S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The present study introduces a new ultra\u2010high\u2010frequency 14\u2010lead electrocardiogram technique (UHF\u2010ECG) for mapping ventricular depolarization patterns and calculation of novel dyssynchrony parameters that may improve the selection of patients and application of cardiac resynchronization therapy (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Components of the ECG in sixteen frequency bands within the 150 to 1000\u2009Hz range were used to create ventricular depolarization maps. The maximum time difference between the UHF QRS complex centers of mass of leads V1 to V8 was defined as ventricular electrical dyssynchrony (e\u2010DYS), and the duration at 50% of peak voltage amplitude in each lead was defined as the duration of local depolarization (Vd). Proof of principle measurements was performed in seven patients with left (left bundle branch block) and four patients with right bundle branch block (right bundle branch block) before and during CRT using biventricular and His\u2010bundle pacing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The acquired activation maps reflect the activation sequence under the tested conditions. e\u2010DYS decreased considerably more than QRS duration, during both biventricular pacing (\u221250% vs \u22128%) and His\u2010bundle pacing (\u221277% vs \u221213%). While biventricular pacing slightly increased Vd, His\u2010bundle pacing reduced Vd significantly (+11% vs \u221236%), indicating the contribution of the fast conduction system. Optimization of biventricular pacing by adjusting VV\u2010interval showed a decrease of e\u2010DYS from 102 to 36\u2009ms with only a small Vd increase and QRS duration decrease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The UHF\u2010ECG technique provides novel information about electrical activation of the ventricles from a standard ECG electrode setup, potentially improving the selection of patients for CRT and application of CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.14299","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T14:50:29Z","timestamp":1575298229000},"page":"300-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Novel ultra\u2010high\u2010frequency electrocardiogram tool for the description of the ventricular depolarization pattern before and during cardiac resynchronization"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-5075","authenticated-orcid":false,"given":"Pavel","family":"Jurak","sequence":"first","affiliation":[{"name":"Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-6358","authenticated-orcid":false,"given":"Karol","family":"Curila","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiocenter, Third Faculty of Medicine Charles University, University Hospital Kralovske Vinohrady Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Leinveber","sequence":"additional","affiliation":[{"name":"International Clinical Research Center St Anne\u02bcs University Hospital Brno Czech Republic"},{"name":"First Department of Internal Medicine\u2010Cardioangiology Faculty of Medicine of Masaryk University, St Anne\u02bcs University Hospital Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Viscor","sequence":"additional","affiliation":[{"name":"Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Plesinger","sequence":"additional","affiliation":[{"name":"Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Smisek","sequence":"additional","affiliation":[{"name":"Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic"},{"name":"Department of Biomedical Engineering, The Faculty of Electrical Engineering and Communication Brno University of Technology Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Prochazkova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiocenter, Third Faculty of Medicine Charles University, University Hospital Kralovske Vinohrady Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Osmancik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiocenter, Third Faculty of Medicine Charles University, University Hospital Kralovske Vinohrady Prague Czech 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