{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:04:59Z","timestamp":1768521899204,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa (AN) is associated with autonomic dysfunction and carries a high risk of sudden death, putatively attributed to ventricular tachyarrhythmias. To date, long\u2010term cardiac monitoring has not been performed to confirm this speculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We assessed the safety and acceptability of an insertable cardiac monitor (ICM) in patients with severe AN with markedly reduced body mass index (BMI), and investigated heart rate (HR) and rhythm before and after weight restoration. Autonomic function was assessed as HR response to a standardized activity protocol at baseline and four additional visits over 360 days. The Florida Patient Acceptance Survey (FPAS) was used to measure ICM acceptability.<\/jats:p><jats:p>During a mean follow\u2010up of 10 months, no ICM\u2010related complications occurred and ICM was well\u2010accepted by the 11 study participants (nine women, aged 19\u201059 years, baseline BMI\u2009=\u200912.7\u2009\u00b1\u20091.6\u2009kg\/m<jats:sup>2<\/jats:sup>). Both resting and peak HR increased with weight restoration and were directly associated with BMI (both <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). No ventricular tachyarrhythmias occurred during the study period, but two participants (18%) experienced eight sinus pauses (3.0\u20107.0\u2009seconds) and three runs of supraventricular tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term cardiac rhythm monitoring with an ICM is feasible, safe, and acceptable in patients with severe AN. Autonomic dysfunction in AN results in not only profound resting bradycardia, but also some degree of chronotropic incompetence, both of which improve with weight restoration. Clinically significant bradyarrhythmias are more common than ventricular tachyarrhythmias in AN, and may represent a competing underlying mechanism for the high risk of sudden death in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14338","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T11:12:12Z","timestamp":1578568332000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long\u2010term cardiac arrhythmia and chronotropic evaluation in patients with severe anorexia nervosa (LACE\u2010AN): A pilot study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-8663","authenticated-orcid":false,"given":"Morteza","family":"Farasat","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology Denver Health and Hospital Authority  Denver Colorado"},{"name":"Department of Medicine University of 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Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Mehler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine  Aurora Colorado"},{"name":"The ACUTE Center for Eating Disorders Denver Health and Hospital Authority  Denver Colorado"},{"name":"Eating Recovery Center  Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mori J.","family":"Krantz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Denver Health and Hospital Authority  Denver Colorado"},{"name":"Department of Medicine University of Colorado School of Medicine  Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1353\/book.98249","volume-title":"Eating Disorders: A Guide to 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