{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:54:50Z","timestamp":1785419690995,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1154992"],"award-info":[{"award-number":["1154992"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1162929"],"award-info":[{"award-number":["1162929"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001173","name":"Cardiac Society of Australia and New Zealand","doi-asserted-by":"publisher","award":["Boehringer Ingelheim Innovation Award"],"award-info":[{"award-number":["Boehringer Ingelheim Innovation Award"]}],"id":[{"id":"10.13039\/501100001173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence and clinical course of atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) is well described, though less so for other inherited cardiomyopathies (familial dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction); and inherited arrhythmia syndromes (long QT syndrome, Brugada syndrome or catecholaminergic polymorphic ventricular tachycardia [CPVT]). We examined the frequency, clinical characteristics and AF\u2010related management and outcomes amongst this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied consecutive probands with inherited cardiomyopathy (n\u2009=\u2009962) and inherited arrhythmia syndromes (n\u2009=\u2009195) evaluated between 2002 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AF was observed in 5% to 31% of patients, with the highest frequency in HCM. Age of AF onset was 45.8\u2009\u00b1\u200921.9 years in the inherited arrhythmia syndromes compared with 53.3\u2009\u00b1\u200915.3 years in the inherited cardiomyopathies, with four CPVT patients developing AF at a median age of 20 years. Overall, 11% of patients with AF had a transient ischemic attack or stroke of which a total of 80% were anticoagulated; with 48% of events occurring at a CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc\u2009&lt;\u20092. Amongst sarcomere\u2010positive HCM, AF was independently associated with age (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.02\u20101.08; <jats:italic>P<\/jats:italic>\u2009=\u2009.0014), left atrial area (OR, 1.11; 95% CI, 1.05\u20101.17; <jats:italic>P<\/jats:italic>\u2009=\u2009.0005) and <jats:italic>MYH7<\/jats:italic> variants (OR, 2.55; 95% CI, 1.16\u20105.61; <jats:italic>P<\/jats:italic>\u2009=\u2009.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Up to one\u2010third of inherited heart disease patients will develop AF. While common general population risk factors are key in patients with HCM, the genotype is independently associated with AF. Amongst inherited arrhythmia syndromes, AF is less common, though often occurs below the age of 50 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14346","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T05:43:05Z","timestamp":1578894185000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiology and clinical characteristics of atrial fibrillation in patients with inherited heart diseases"],"prefix":"10.1111","volume":"31","author":[{"given":"Alexandra","family":"Butters","sequence":"first","affiliation":[{"name":"Agnes Ginges Centre for Molecular Cardiology at Centenary Institute The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Isbister","sequence":"additional","affiliation":[{"name":"Agnes Ginges Centre for Molecular Cardiology at Centenary Institute The University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Medi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariharan","family":"Raju","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Department of Cardiology Concord Repatriation General Hospital  Sydney 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