{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:53:43Z","timestamp":1768816423071,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["OL 605\/1\u20101 to GO."],"award-info":[{"award-number":["OL 605\/1\u20101 to GO."]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the significance of early recurrence (ER) of atrial tachyarrhythmias after pulmonary vein isolation (PVI) on the development of late recurrence (LR) and to redefine the blanking period during which an ER is considered nonspecific.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 713 patients undergoing their first PVI for paroxysmal or persistent atrial fibrillation between January 2012 and December 2017 were included. All patients were followed\u2010up for 12 months according to clinical and outpatient routine and were screened for any atrial tachyarrhythmia lasting &gt;30 seconds occurring during the first 3 months postablation (ER) and after the 3 months blanking period (LR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with ER compared to those without ER had significantly more LR (74.5% vs 16.5% vs, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The occurrence of ER during the first, second and third months showed increasing LR rates of 35.2%, 67.9%, and 94.8%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Receiver operator characteristic analysis revealed a blanking period of 46 days with the highest sensitivity (68.1%) and specificity (96.5%). Later timing and longer time span of ER were independent predictors for LR in multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ER is a strong predictor for LR. Our study advocates a shortening of the post\u2010PVI blanking period followed by a \u201cgray zone\u201d up to 3 months where individualized therapeutic decisions based on additional risk factors should be considered. We suggest that the ER time span might serve as such a predictor identifying patients at the highest risk for LR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14368","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T04:54:45Z","timestamp":1580100885000},"page":"674-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early recurrences of atrial tachyarrhythmias post pulmonary vein isolation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-0414","authenticated-orcid":false,"given":"Gesa","family":"von Olshausen","sequence":"first","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Uijl","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Utrecht University  The Netherlands"},{"name":"Health Data Research UK London, Institute for Health Informatics University College London  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Jensen\u2010Urstad","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Schwieler","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Drca","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Bastani","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Tapanainen","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ott","family":"Saluveer","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Bourke","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Kenneb\u00e4ck","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Insulander","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Deisenhofer","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Klinik f\u00fcr Herz\u2010 und Kreislauferkrankungen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieder","family":"Braunschweig","sequence":"additional","affiliation":[{"name":"Heart and Vascular Division Karolinska University Hospital Stockholm 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