{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:06:07Z","timestamp":1791014767781,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The AdaptivCRT (aCRT) algorithm continuously adjusts cardiac resynchronization therapy (CRT) according to intrinsic atrioventricular conduction, providing synchronized left ventricular pacing in patients with normal PR interval and adaptive BiV pacing in patients with prolonged PR interval. Previous analyses demonstrated an association between aCRT and clinical benefit. We evaluated the incidence of patient mortality and atrial fibrillation (AF) with aCRT compared with standard CRT in a real\u2010world population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients enrolled in the Medtronic Personalized CRT Registry and implanted with a CRT from 2013\u20102018 were divided into aCRT ON or standard CRT groups based upon device\u2010stored data. A Frailty survival model was used to evaluate the potential survival benefit of aCRT, accounting for patient heterogeneity and center variability. Daily AF burden and first device\u2010detected AF episodes of various durations were recorded by the device during follow\u2010up.<\/jats:p><jats:p>A total of 1814 CRT patients with no reported long\u2010standing AF history at implant were included. Mean follow\u2010up time was 26.1\u2009\u00b1\u200916.5 months and 1162 patients (64.1%) had aCRT ON. Patient survival probability at 36 months was 88.3% for aCRT ON and 83.7% for standard CRT (covariate\u2010adjusted hazard ratio [HR]\u2009=\u20090.71, 95% CI: 0.53\u20100.96, <jats:italic>P<\/jats:italic>\u2009=\u2009.028). Mean AF burden during follow\u2010up was consistently lower in aCRT ON patients compared with standard CRT. At 36 months, the probability of AF was lower in patients with aCRT ON, regardless of which AF definition threshold was applied (6 minutes\u201030 days, all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of the AdaptivCRT algorithm was associated with improved patient survival and lower incidence of AF in a real\u2010world, prospective, nonrandomized registry.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14376","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T10:02:11Z","timestamp":1580724131000},"page":"825-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Real\u2010world behavior of CRT pacing using the AdaptivCRT algorithm on patient outcomes: Effect on mortality and atrial fibrillation incidence"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-1188","authenticated-orcid":false,"given":"Jagmeet P.","family":"Singh","sequence":"first","affiliation":[{"name":"Cardiology Division Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-9464","authenticated-orcid":false,"given":"Yong\u2010Mei","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-844X","authenticated-orcid":false,"given":"Maurizio","family":"Lunati","sequence":"additional","affiliation":[{"name":"Department of Cardiology\/Cardiac\u2010Thoracic\u2010Vascular Surgery Ospedale Niguarda  Niguarda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene S.","family":"Chung","sequence":"additional","affiliation":[{"name":"The Lindner Clinical Research Center The Heart and Vascular Center at the Christ Hospital  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Li","sequence":"additional","affiliation":[{"name":"Medtronic, Plc  Mounds View Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Smeets","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology GenesisCare  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1161\/CIRCULATIONAHA.106.178233","article-title":"American College of Cardiology\/American Heart Association Task Force, European Society of Cardiology Committee for Practice Guidelines, European Heart Rhythm Association, Heart Rhythm Society: ACC\/AHA\/ESC 2006 Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention Of Sudden Cardiac Death: a report of the American College of Cardiology\/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in 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