{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:54:55Z","timestamp":1785750895917,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The LAmbre (LifeTech Scientific, Shenzhen, China) is a novel occluder for left atrial appendage closure (LAAC) in patients with atrial fibrillation. This study compares late clinical outcomes of LAmbre and the established Amplatzer devices (Abbott, St Paul, MN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2012 and 2018, 265 consecutive patients underwent LAAC with LAmbre and Amplatzer devices at a single center. After a 3:1 propensity score matching, 40 (LAmbre) vs 107 (Amplatzer) patients were compared by the primary efficacy endpoint of all\u2010cause stroke, systemic embolism and cardiovascular\/unexplained death, the primary safety endpoint of major periprocedural complications and major bleeding events at follow\u2010up, and the combined hazard endpoint, a composite of all the above\u2010mentioned hazards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age 75.6\u2009\u00b1\u20098.9 (LAmbre) vs 75.5\u2009\u00b1\u20099.0 (Amplatzer) years, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score 4.8\u2009\u00b1\u20091.7 vs 4.8\u2009\u00b1\u20091.7 and HAS\u2010BLED score 3.1\u2009\u00b1\u20090.9 vs 3.2\u2009\u00b1\u20090.8 were similar. After 3.6\u2009\u00b1\u20091.9 vs 2.5\u2009\u00b1\u20091.4 years, the clinical efficacy (12\/146, 8.2% [LAmbre] vs 28\/266, 10.5% [Amplatzer]; hazard ratio [HR], 0.73; 95% confidence interval [CI], 0.38\u20101.40; <jats:italic>P<\/jats:italic>\u2009=\u2009.34) and safety (5\/146, 3.4% vs 14\/266, 5.3%; HR, 0.47; 95% CI, 0.14\u20101.6; <jats:italic>P<\/jats:italic>\u2009=\u2009.22), as well as the combined hazard endpoint (15\/146, 10.3% vs 36\/266, 13.6%; HR, 0.67; 95% CI, 0.36\u20101.25; <jats:italic>P<\/jats:italic>\u2009=\u2009.21) were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the presented report, in patients with nonvalvular atrial fibrillation, the LAmbre offered similar long\u2010term efficacy and safety in comparison to Amplatzer devices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14398","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:13:37Z","timestamp":1582085617000},"page":"934-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Late clinical outcomes of lambre versus amplatzer occluders for left atrial appendage closure"],"prefix":"10.1111","volume":"31","author":[{"given":"Steffen","family":"Schnupp","sequence":"first","affiliation":[{"name":"Department of Cardiology Klinikum Coburg  Coburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 4th Hospital of Harbin Medical University  Harbin China"},{"name":"Department of Cardiology Anzhen Hospital, Capital Medical University  Beijing 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