{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:20:02Z","timestamp":1768422002932,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","award":["00180271"],"award-info":[{"award-number":["00180271"]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aimed to assess the predictors of new supraventricular tachycardia (SVT) and the association of new SVT with subsequent clinical outcomes among mild heart failure (HF) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The study population comprised patients enrolled in MADIT\u2010CRT, after exclusion of patients with atrial arrhythmias before enrollment (N\u2009=\u2009325). Multivariate analysis was used to identify predictors of new\u2010onset SVT and the association of time\u2010dependent development of SVT with subsequent ventricular tachyarrhythmic events (VTEs), HF\u2010hospitalizations, and death. SVT burden was categorized into three groups based on the number of episodes per patient; (a) Low &lt;10, (b) Intermediate \u226510 but &lt;20, and (c) High \u226520. During mean follow up of 3.4\u2009\u00b1\u20091.1 years, 41(3%) subjects developed new SVT. African American race, diastolic blood pressure (DBP) &gt;80\u2009mmHg and prior non sustained ventricular arrhythmia were independent predictors for SVT. Multivariate analysis showed that the development of time\u2010dependent SVT was associated with a &gt;4\u2010fold increased risk for VTEs (HR\u2009=\u20094.3; 95% CI: 1.6\u201011.7; <jats:italic>P<\/jats:italic>\u2009=\u2009.004) and with a &gt;6\u2010fold increased risk for all\u2010cause mortality (HR\u2009=\u20096.5; 95% CI: 2.3\u201018.7; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), but not with HF hospitalizations (HR\u2009=\u20092.2; 95% CI: 0.7\u20107.2; <jats:italic>P<\/jats:italic>\u2009=\u2009.17). Intermediate, and high SVT\u2010burden were each independent risk factors for death when compared with Low burden (HR\u2009=\u20099.1; <jats:italic>P<\/jats:italic>\u2009=\u2009.03, and HR\u2009=\u200919.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with mild HF, the development of new\u2010onset SVT after device implantation is related to distinct baseline clinical and epidemiologic characteristics and is associated with a significant increase in subsequent adverse outcomes, including VTEs and death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14416","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T12:23:24Z","timestamp":1582892604000},"page":"1099-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role and outcomes of new supraventricular tachycardia among patients with mild heart failure"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5025","authenticated-orcid":false,"given":"Arwa","family":"Younis","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-3325","authenticated-orcid":false,"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-289X","authenticated-orcid":false,"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9384","authenticated-orcid":false,"given":"Mehmet K.","family":"Aktas","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New 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tachycardia triggering polymorphic ventricular tachycardia","volume":"5","author":"Oomen Ad WGJ","year":"2019","journal-title":"HearRhythm Journal"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03611.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01784-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90508-7"}],"container-title":["Journal of Cardiovascular 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