{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:10:49Z","timestamp":1774437049872,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370303"],"award-info":[{"award-number":["81370303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770331"],"award-info":[{"award-number":["81770331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>His\u2010Purkinje system pacing has been demonstrated as a synchronized ventricular pacing strategy via pacing His\u2010Purkinje system directly, which can decrease the incidence of adverse cardiac structure alteration compared with right ventricular pacing (RVP). The purpose of this meta\u2010analysis was to compare the effects of His\u2010Purkinje system pacing and RVP in patients with bradycardia and cardiac conduction dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from the establishment of databases up to 15 December 2019. Studies on long\u2010term clinical outcomes of His\u2010Purkinje system pacing and RVP were included. Chronic paced QRS duration, chronic pacing threshold, left ventricular ejection fraction (LVEF), left ventricular end\u2010diastolic volume (LVEDV), left ventricular end\u2010systolic volume (LVESV), all\u2010cause mortality, and heart failure hospitalization were collected for meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 studies comprising 2348 patients were included in this meta\u2010analysis. Compared with RVP group, patients receiving His\u2010Purkinje system pacing showed improvement of LVEF (mean difference [MD], 5.65; 95% confidence interval [CI], 4.38\u20106.92), shorter chronic paced QRS duration (MD, \u2212\u200939.29; 95% CI, \u2212\u200941.90 to \u2212\u200936.68), higher pacing threshold (MD, 0.8; 95% CI, 0.71\u20100.89) and lower risk of heart failure hospitalization (odds ratio [OR], 0.65; 95% CI, 0.44\u20100.96) during the follow\u2010up. However, no statistical difference existed in LVEDV, LVESV and all\u2010cause mortality between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis suggests that His\u2010bundle pacing is more suitable for the treatment of patients with bradycardia and cardiac conduction dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14445","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T11:59:00Z","timestamp":1584014340000},"page":"1202-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The long\u2010term therapeutic effects of His\u2010Purkinje system pacing on bradycardia and cardiac conduction dysfunction compared with right ventricular pacing: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-5387","authenticated-orcid":false,"given":"Jin\u2010Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital Affiliated to Nanjing Medical University  Wuxi China"},{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Qin","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital Affiliated to Nanjing Medical University  Wuxi China"},{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital 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