{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:17:49Z","timestamp":1791850669794,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In December 2019, the world started to face a new pandemic situation, the severe acute respiratory syndrome\u2010coronavirus 2 (SARS\u2010CoV\u20102). Although coronavirus disease (COVID\u201019) clinical manifestations are mainly respiratory, major cardiac complications are being reported. Cardiac manifestations etiology seems to be multifactorial, comprising direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, ACE2\u2010receptors downregulation, drug toxicity, endogenous catecholamine adrenergic status, among others. Studies evaluating patients with COVID\u201019 presenting cardiac injury markers show that it is associated with poorer outcomes, and arrhythmic events are not uncommon. Besides, drugs currently used to treat the COVID\u201019 are known to prolong the QT interval and can have a proarrhythmic propensity. This review focus on COVID\u201019 cardiac and arrhythmic manifestations and, in parallel, makes an appraisal of other virus epidemics as SARS\u2010CoV, Middle East respiratory syndrome coronavirus, and H1N1 influenza.<\/jats:p>","DOI":"10.1111\/jce.14479","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T07:38:18Z","timestamp":1586417898000},"page":"1003-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":501,"title":["Cardiac and arrhythmic complications in patients with COVID\u201019"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-2054","authenticated-orcid":false,"given":"Adriano Nunes","family":"Kochi","sequence":"first","affiliation":[{"name":"Heart Rhythm Center Centro Cardiologico Monzino IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana 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