{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:49:56Z","timestamp":1769107796347,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to investigate the association between T\u2010wave morphology and impaired left ventricular ejection fraction (LVEF) in patients with complete left bundle branch block (cLBBB), and the predictive value of T\u2010wave morphology for response to cardiac resynchronization therapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We enrolled 189 patients with cLBBB on electrocardiogram performed between January 2007 and December 2011 who underwent standard echocardiography. Repolarization parameters, including the QRS\u2010to\u2010T angle (TCRT), T\u2010wave morphology dispersion (TMD), T\u2010wave loop area (PL), and T\u2010wave residuum (TWR), were reconstructed from digital standard 12\u2010lead electrocardiograms by T\u2010wave morphology analysis. CRT response was defined as \u226515% reduction in left ventricular end\u2010systolic volume at 12 months after CRT implantation. The clinical outcome endpoint was a composite of heart failure hospitalization, heart transplantation, or death during follow up (mean, 5.8 years). On logistic regression, a higher heart rate, longer QRS duration, increased TMD, and larger TWR were all independently associated with LVEF\u2009&lt;\u200940%. Among 40 patients who underwent CRT, those with a larger TMD (<jats:italic>P<\/jats:italic>\u2009=\u2009.007), larger PL (<jats:italic>P<\/jats:italic>\u2009=\u2009.025), and more negative TCRT (<jats:italic>P<\/jats:italic>\u2009=\u2009.015) had better response to CRT. A large TMD (<jats:italic>P<\/jats:italic>\u2009=\u2009.018) and large PL (<jats:italic>P<\/jats:italic>\u2009=\u2009.003) were also independent predictors of the clinical outcome endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increases in repolarization heterogeneity in patients with cLBBB are associated with impaired LVEF. A large TMD and large PL may be useful as additional predictors of response to CRT, improving patient selection for CRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14488","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T12:51:13Z","timestamp":1586523073000},"page":"1770-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increases in repolarization heterogeneity predict left ventricular systolic dysfunction and response to cardiac resynchronization therapy in patients with left bundle branch block"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-7850","authenticated-orcid":false,"given":"Hui\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Liong","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Institute of Epidemiology College of Public Health  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chung","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Communication Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology College of Public Health  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.08.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_8_4_1","first-page":"1787","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. 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