{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:47Z","timestamp":1791511367242,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Moderate sedation (MS) during cryoballoon ablation (CBA) avoids risks of general anesthesia (GA) and improves electrophysiology (EP) lab throughput. However, one barrier to the use of MS is the potential for patient discomfort. The objective of this study was to compare patient\u2010reported outcome measures following CBA for paroxysmal atrial fibrillation (pAF) under MS and GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Consecutive patients undergoing a first CBA for pAF under GA or MS were prospectively enrolled. The sedation method was assigned based on patient and provider preference, and perceived airway risk. The primary outcomes were quality of recovery (measured using a validated 40 question survey; QoR\u201040) and likelihood to recommend (LTR) the procedure and sedation method (measured by Likert scale). Secondary outcomes were acute pulmonary vein (PV) isolation rate, procedure, fluoroscopy and ablation times, and complication rates. Forty\u2010seven GA and 53 MS patients were included. The mean age was 64.9\u2009\u00b1\u20099.4\u2009years and mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score was 2.0\u2009\u00b1\u20091.4. QoR\u201040 scores were 184.6\u2009\u00b1\u200916.4 for GA and 187.6\u2009\u00b1\u200910.2 for MS (<jats:italic>P<\/jats:italic>\u2009=\u2009.28). LTR responses were similar between groups. Mean procedure times were 148.2\u2009\u00b1\u200956.0\u2009minutes for GA and 129.4\u2009\u00b1\u200931.4\u2009minutes for MS (<jats:italic>P<\/jats:italic>\u2009=\u2009.038). Fluoroscopy and ablation times were similar between groups. A total of 100% (409\/409) of PVs were acutely isolated. One hemopericardium occurred in the MS group requiring pericardiocentesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MS for CBA offers an alternative to GA that is safe and well\u2010tolerated by patients with comparable success rates and improved EP lab throughput.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14547","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T05:36:29Z","timestamp":1589348189000},"page":"1579-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Patient\u2010reported outcomes after cryoballoon ablation are equivalent between moderate sedation and general anesthesia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-3520","authenticated-orcid":false,"given":"Jeremiah","family":"Wasserlauf","sequence":"first","affiliation":[{"name":"Division of Cardiology Northwestern University 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