{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:57:03Z","timestamp":1786712223671,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The novel two\u2010lead cardiac resynchronization therapy (CRT)\u2010DX system utilizes a floating atrial dipole on the implantable cardioverter\u2010defibrillator lead, and when implanted with a left ventricular (LV) lead, offers a two\u2010lead CRT system with AV synchrony. This study compared complication rates and CRT response among subjects implanted with a two\u2010lead CRT\u2010DX system to those subjects implanted with a standard three\u2010lead CRT\u2010D system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A total of 240 subjects from the Sentus QP\u2014Extended CRT Evaluation with Quadripolar Left Ventricular Leads postapproval study were selected to identify 120 matched pairs based on similar demographic characteristics using a Greedy algorithm. The complication\u2010free rate was evaluated as the primary endpoint. All\u2010cause mortality, heart failure hospitalizations, device diagnostic data, New York Heart Association (NYHA) class improvement, and defibrillator therapy were evaluated from clinical data, in\u2010office interrogations, and remote monitoring throughout the follow\u2010up period. Complication\u2010free survival favored the CRT\u2010DX group with 92.5% without a major complication compared to 85.0% in the CRT\u2010D cohort (<jats:italic>P<\/jats:italic>\u2009=\u2009.0495; 95% confidence interval: 0.1%\u201014.9%) over a mean follow\u2010up of 1.3 and 1.4 years, respectively. Incidence of all\u2010cause mortality, heart failure hospitalizations, NYHA changes at 6 months postimplant, and percent of LV pacing during CRT therapy were similar in both device cohorts. Inappropriate shocks were more frequent in the CRT\u2010D cohort with 5.8% of subjects receiving an inappropriate shock vs 0.8% in the CRT\u2010DX cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this subanalysis demonstrate that the CRT\u2010DX system can provide similar CRT responses and significantly fewer complications when compared to a similar cohort with a conventional three\u2010lead CRT\u2010D system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14552","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T03:13:55Z","timestamp":1589598835000},"page":"1784-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel two\u2010lead cardiac resynchronization therapy system provides equivalent CRT responses with less complications than a conventional three\u2010lead system: Results from the QP ExCELs lead 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