{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:12:54Z","timestamp":1761808374592,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL116280","R01 HL142893"],"award-info":[{"award-number":["R01 HL116280","R01 HL142893"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The association of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) with epicardial and surface ventricular tachycardia (VT) electrogram features, in nonischemic cardiomyopathy (NICM), is unknown. We sought to define the association of LGE and viable wall thickness with epicardial electrogram features and exit site paced QRS duration in patients with NICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 19 patients (age 53.5\u2009\u00b1\u200911.5 years) with NICM (ejection fraction 40.2\u2009\u00b1\u200913.2%) underwent CMR before VT ablation. LGE transmurality was quantified on CMR and coregistered with 2294 endocardial and 2724 epicardial map points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both bipolar and unipolar voltage were associated with transmural signal intensity on CMR. Longer electrogram duration and fractionated potentials were associated with increased LGE transmurality, but late potentials or local abnormal ventricular activity were more prevalent in nontransmural versus transmural LGE regions (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Of all critical VT sites, 19% were located adjacent to regions with LGE but normal bipolar and unipolar voltage. Exit site QRS duration was affected by LGE transmurality and intramural scar location, but not by wall thickness, at the impulse origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with NICM and VT, LGE is associated with epicardial electrogram features and may predict critical VT sites. Additionally, exit site QRS duration is affected by LGE transmurality and intramural location at the impulse origin or exit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14618","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T07:19:15Z","timestamp":1592291955000},"page":"2032-2040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of scar distribution with epicardial electrograms and surface ventricular tachycardia QRS duration in nonischemic cardiomyopathy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-1235","authenticated-orcid":false,"given":"Jaeseok","family":"Park","sequence":"first","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Division of Cardiology, Department of Internal Medicine Mediplex Sejong Hospital  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Desjardins","sequence":"additional","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-8899","authenticated-orcid":false,"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Zghaib","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":false,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4857","authenticated-orcid":false,"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-6149","authenticated-orcid":false,"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob J.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-0259","authenticated-orcid":false,"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania 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