{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:24:54Z","timestamp":1790771094609,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac sympathetic denervation (CSD) is utilized for the management of ventricular tachycardia (VT) in structural heart disease when refractory to radiofrequency ablation (RFA) or when patient\/VT characteristics are not conducive to RFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied consecutive patients who underwent CSD at our institution from 2009 to 2018 with VT requiring repeat RFA post\u2010CSD. Patient demographics, VT\/procedural characteristics, and outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six patients had CSD, 16 patients underwent RFA for VT post\u2010CSD. There were 15 male and 1 female patients with mean age of 54.2\u2009\u00b1\u200913.2 years. Fourteen patients had nonischemic cardiomyopathy. A mean of 2.0\u2009\u00b1\u20090.8 RFAs for VT was unsuccessful before the patient undergoing CSD. The median time between CSD and RFA was 104 days (interquartile range [IQR]\u2009=\u200915\u2013241). The clinical VT cycle length was significantly increased after CSD both spontaneously on ECG and\/or ICD interrogation (355\u2009\u00b1\u200973\u2009ms pre\u2010CSD vs. 422\u2009\u00b1\u200994\u2009ms post\u2010CSD, <jats:italic>p<\/jats:italic>\u2009=\u2009.001) and intraprocedurally (406\u2009\u00b1\u200986\u2009ms pre\u2010CSD vs. 457\u2009\u00b1\u200988\u2009ms post\u2010CSD, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). Two patients had polymorphic and 14 had monomorphic VT (MMVT) pre\u2010CSD, and all patients had MMVT post\u2010CSD. The proportion of mappable, hemodynamically stable VTs increased from 35% during pre\u2010CSD RFA to 58% during post\u2010CSD RFA (<jats:italic>p<\/jats:italic>\u2009=\u2009.038). At median follow\u2010up of 413 days (IQR\u2009=\u200943\u20131840) after RFA, eight patients had no further VT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RFA for recurrent MMVT post\u2010CSD is a reasonable treatment option with intermediate\u2010term clinical success in 50% of patients. Clinical VT cycle length was significantly increased after CSD with associated improvement in mappable, hemodynamically tolerated VT during RFA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14624","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T05:55:05Z","timestamp":1592459705000},"page":"2382-2392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recurrent ventricular tachycardia after cardiac sympathetic denervation: Prolonged cycle length with improved hemodynamic tolerance and ablation outcomes"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-3817","authenticated-orcid":false,"given":"Justin","family":"Hayase","sequence":"first","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Dusi","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc","family":"Do","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olujimi A.","family":"Ajijola","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marmar","family":"Vaseghi","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Lee","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Hoftman","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha'Shonda","family":"Revels","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F.","family":"Buch","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-9084","authenticated-orcid":false,"given":"Houman","family":"Khakpour","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Fujimura","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Krokhaleva","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Macias","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sorg","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gima","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Pavez","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel G.","family":"Boyle","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyanam","family":"Shivkumar","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-5726","authenticated-orcid":false,"given":"Jason S.","family":"Bradfield","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.036"},{"key":"e_1_2_8_3_1","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","author":"Al\u2010Khatib SM","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.035"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615244"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.05.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90841-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00533-5"},{"key":"e_1_2_8_9_1","first-page":"2019","article-title":"HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias","author":"Cronin EM","year":"2019","journal-title":"Heart Rhythm"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12858"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.02.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01106.2011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.03.052"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00434.2013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00575.2016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.03.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.09.016"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.14624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:21:31Z","timestamp":1693689691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/jce.14624"],"URL":"https:\/\/doi.org\/10.1111\/jce.14624","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"assertion":[{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}