{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:48:30Z","timestamp":1771490910305,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In cardiac resynchronization therapy, pacing the left ventricle (LV) at sites of prolonged electrical delay is associated with better outcomes. We sought to characterize the interrelationships between intrinsic, right\u2010ventricular (RV)\u2010paced, and LV\u2010paced interventricular delays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The following electrical timings were measured at implantation for all electrodes of the LV quadripolar leads: QLV, interventricular delay in intrinsic rhythm (RVs\u2010LVs), in RV\u2010paced rhythm (RVp\u2010LVs), and in LV\u2010paced rhythm (LVp\u2010RVs). We included 32 patients (78% men, age 72 years, LV ejection fraction 29%, left bundle branch block 84%). QLV and RVs\u2010LVs were correlated (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), as were RVs\u2010LVs and RVp\u2010LVs (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.27, <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and RVp\u2010LVs and LVp\u2010RVs (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Direction of activation along the four LV lead electrodes was concordant between RVs\u2010LVs and RVp\u2010LVs in only 17 (53%) patients. The latest\u2010activated electrodes in RVs\u2010LVs and RVp\u2010LVs were concordant in 26 (81%) patients, adjacent in 3 (9%) patients, and remote in 3 (9%) patients. Biventricular\u2010paced QRS duration varied by more than 10\u2009ms between the two electrodes in half of the patients with dissimilar latest electrodes. Among the seven echocardiographic nonresponders at 6 months, the programmed electrode was remote from the latest electrode in RVs\u2010LVs in five patients and in RVp\u2010LVs in three patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intrinsic and RV\u2010paced interventricular electrical delays are correlated, but there is substantial heterogeneity between patients. The latest\u2010activated electrode may be different between RVs\u2010LVs and RVp\u2010LVs, and this might have important implications in selecting the optimal LV vector.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14629","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T12:00:35Z","timestamp":1592654435000},"page":"2405-2414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Interrelationships between interventricular electrical delays in cardiac resynchronization therapy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-0845","authenticated-orcid":false,"given":"Ghassan","family":"Moubarak","sequence":"first","affiliation":[{"name":"Department of Electrophysiology and Pacing Centre M\u00e9dico\u2010Chirurgical Ambroise Par\u00e9  Neuilly\u2010sur\u2010Seine 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