{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:18Z","timestamp":1791821478453,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cryoballoon ablation (CBA) and radiofrequency ablation (RFA) are the preferred modalities for catheter ablation of atrial fibrillation (AF). Technological advances have improved procedural outcomes, warranting an updated comparison. We sought to evaluate the efficacy and safety of CBA\u20132nd generation (CBA\u20102G) in comparison to RFA\u2010contact force (RFA\u2010CF) in patients with AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Cochrane, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> databases were searched until 03\/01\/2020 for relevant studies comparing CBA\u20102G versus RFA\u2010CF in patients undergoing initial catheter ablation for AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 studies, involving 11\u2009793 patients were included. There was no difference between the two groups in the outcomes of freedom from atrial arrhythmia (<jats:italic>p<\/jats:italic>\u2009=\u2009.67) and total procedural complications (<jats:italic>p<\/jats:italic>\u2009=\u2009.65). There was a higher incidence of phrenic nerve palsy in CBA\u20102G (odds ratio: 10.7; 95% confidence interval [CI]: 5.85 to 19.55;\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Procedure duration was shorter (mean difference:\u00a0\u221231.32\u2009min; 95% CI:\u00a0\u221240.73 to \u221221.92; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and fluoroscopy duration was longer (+3.21\u2009min; 95% CI: 1.09 to 5.33; <jats:italic>p<\/jats:italic>\u2009=\u2009.003) in CBA\u20102G compared to RFA\u2010CF. In the subgroup analyses of patients with persistent AF and\u00a0&gt;1 freeze lesion delivered per vein, there was no difference in freedom from atrial arrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In AF patients undergoing initial ablation, CBA\u20102G and RFA\u2010CF were equally efficacious. The procedure duration was shorter, but with a higher incidence of phrenic nerve palsy in CBA\u20102G. In patients with persistent AF, there was no difference in the efficacy between CBA\u20102G or RFA\u2010CF techniques.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14676","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T08:27:24Z","timestamp":1594888044000},"page":"2559-2571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A systematic review and meta\u2010analysis comparing second\u2010generation cryoballoon and contact force radiofrequency ablation for initial ablation of paroxysmal and persistent atrial fibrillation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-9231","authenticated-orcid":false,"given":"Venkatesh","family":"Ravi","sequence":"first","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhushan","family":"Poudyal","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine John H Stroger Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanjali","family":"Pulipati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Larsen","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousik","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Trohman","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-476X","authenticated-orcid":false,"given":"Parikshit S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-4317","authenticated-orcid":false,"given":"Henry D.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00956.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1232-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X15666181212102419"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.01.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux274"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_7_10_1","unstructured":"HigginsJPT ThomasJ ChandlerJ et al. 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