{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:24Z","timestamp":1760123004311,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantable cardioverter defibrillators (ICDs) reduce all\u2010cause mortality among cardiomyopathy patients. Whether or not antitachycardia pacing (ATP) is equally effective in ischemic (ICM) and nonischemic (NICM) cardiomyopathy patients remains poorly understood. We describe the distribution of monomorphic (MVT) and non\u2010monomorphic (polymorphic ventricular tachycardia\/ventricular fibrillation [PVT\/VF]) ventricular tachyarrhythmias among ICM and NICM primary prevention patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This patient\u2010level meta\u2010analysis included primary prevention patients from the Shock\u2010Less (<jats:italic>n<\/jats:italic>\u2009=\u20093519), PainFree SST (<jats:italic>n<\/jats:italic>\u2009=\u20091917), and PREPARE (<jats:italic>n<\/jats:italic>\u2009=\u2009690) studies. Distribution of MVT and PVT\/VF events were compared with <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> tests. ATP success was estimated using a generalized estimating equation model to correct for multiple episodes for a patient between cohorts for slow (\u2265320\u2009ms) and fast (240\u2013310\u2009ms) MVTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 6126 patients, 714 (29% NICM, age 66\u2009\u00b1\u200913\u2009years, female 18%, EF\u2009=\u200929\u2009\u00b1\u200912%) had a total of 4444 treated ventricular tachyarrhythmia episodes. The rate of individuals treated for MVT or PVT\/VF was comparable between ICM (11.9%) and NICM (11.2%) over 21\u2009\u00b1\u200910 months. In addition, the distribution of MVT (76% ICM vs. 71% NICM) and PVT\/VF (15% ICM vs. 20% NICM) was not significantly different (<jats:italic>p<\/jats:italic>\u2009=\u2009.28). Among MVT episodes, the average tachycardia cycle lengths (332\u2009\u00b1\u200958\u2009ms ICM vs. 313\u2009\u00b1\u200940\u2009ms NICM; <jats:italic>p<\/jats:italic>\u2009=\u2009.27) were similar, as was the likelihood of ATP\u2010associated termination (74.6% ICM vs. 76.4% NICM; <jats:italic>p<\/jats:italic>\u2009=\u2009.58). Overall, ATP success was higher for slow (\u2265320\u2009ms) MVT versus faster (240\u2013310\u2009ms) episodes (84.1% vs. 69%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a large cohort of primary prevention ICD patients, ICM and NICM patients have similar rates and proportions of MVT and PVT\/VF episodes. ATP\u2010associated termination of MVT was comparable between the two groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14688","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T07:22:24Z","timestamp":1595488944000},"page":"2720-2726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics of ventricular tachyarrhythmias and their susceptibility to antitachycardia pacing termination in patients with ischemic and nonischemic cardiomyopathy: A patient\u2010level meta\u2010analysis of three large clinical trials"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-9115","authenticated-orcid":false,"given":"Alan","family":"Cheng","sequence":"first","affiliation":[{"name":"Medtronic  Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyoung","family":"Joung","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Medtronic  Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi","family":"Koehler","sequence":"additional","affiliation":[{"name":"Medtronic  Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Lexcen","sequence":"additional","affiliation":[{"name":"Medtronic  Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-8429","authenticated-orcid":false,"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide Hospital  Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical College of Virginia  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.549659"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.11.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.01.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.5.990"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(86)80025-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1988.tb04551.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219533"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13760"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq164"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145610.64014.E4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.03.022"}],"container-title":["Journal of Cardiovascular 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