{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:47:41Z","timestamp":1767084461173,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic left bundle branch block (LBBB) can lead to LBBB\u2010mediated cardiomyopathy from left ventricular dysynchrony. His\u2010bundle pacing (HBP) results in direct electrical synchrony using the native His\u2010Purkinje system, providing a novel treatment for this cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the feasibility of HBP for cardiac resynchronization therapy (CRT) in LBBB\u2010mediated cardiomyopathy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective database review was conducted on patients who underwent CRT by the HBP capable provider at Indiana University Health and Eskenazi Hospital from August 2015 to August 2017. A subset of patients who met the predefined syndrome criteria of LBBB\u2010mediated cardiomyopathy who underwent HBP were identified. Clinical, echocardiographic, and electrocardiographic variables were extracted at baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients had cardiomyopathy and LBBB. Among those two were lost to follow\u2010up. Seven patients were included in the analysis. The average time from device implantation to the last follow\u2010up was 14.5 months. Left ventricular ejection fraction improved on average from 25% to 50% (<jats:italic>p<\/jats:italic>\u2009=\u2009.0001). The left ventricular end\u2010systolic dimension decreased from 47 to 37\u2009mm (<jats:italic>p<\/jats:italic>\u2009=\u2009.003) and the left ventricular end\u2010diastolic dimension decreased from 55 to 48\u2009mm (<jats:italic>p<\/jats:italic>\u2009=\u2009.03). QRS duration with HBP\u2010CRT decreased from 152 to 115\u2009ms. New York Heart Association classification improved from an average of 2.7\u20132.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HBP is a viable technique for pursuing CRT in patients with LBBB\u2010mediated cardiomyopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14692","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T10:35:01Z","timestamp":1595759701000},"page":"2730-2736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["His\u2010bundle pacing: A novel treatment for left bundle branch block\u2010mediated cardiomyopathy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-6569","authenticated-orcid":false,"given":"Rajeev","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Cardiology Washington University St. Louis Missouri 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