{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:41:12Z","timestamp":1772109672702,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ESCAPE\u2010NET (733381)"],"award-info":[{"award-number":["ESCAPE\u2010NET (733381)"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The current knowledge of idiopathic ventricular fibrillation (IVF) is limited. We aimed to investigate the nature of IVF, including clinical assessment and later diagnosis, and risk factors of implantable cardioverter defibrillator (ICD) therapy in the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2007 and 2019 we systematically identified all patients from Rigshospitalet, Denmark, with a resuscitated sudden cardiac arrest (SCA) with no identifiable cause. All patients were followed routinely in the ICD outpatient clinic and the majority also in an inherited heart disease outpatient clinic. Outcomes were analysed with Cox regressions models and cumulative incidence curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 84 patients with an initial diagnosis of IVF; of these, three (3.6%) patients were later diagnosed with a cardiac disease. The remaining IVF patients (<jats:italic>n<\/jats:italic>\u2009=\u200981, median age 45 years; men 71.6%) were followed a median follow\u2010up of 5.2 years (interquartile range, 2.0\u20137.6). A total of 24 (29.6%) patients had appropriate ICD therapy and 12 (14.8%) patients had inappropriate ICD therapy. No predominant type of ventricular arrhythmia at first appropriate ICD therapy was observed. Early repolarization at baseline was not associated with an increased risk of appropriate ICD therapy (<jats:italic>P<\/jats:italic>\u2009=\u2009.842). Repeated cardiac arrest at index SCA increased the risk of appropriate ICD therapy (hazard ratio, 2.63 [95% CI, 1.08\u20136.40; <jats:italic>P<\/jats:italic>\u2009=\u2009.033]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients remained idiopathic throughout the follow\u2010up period and the overall long\u2010term prognosis of IVF was good. Repeated cardiac arrest at index SCA was a risk factor of appropriate ICD therapy and early repolarization was not associated with an increased risk of appropriate ICD therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14696","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T16:26:27Z","timestamp":1595953587000},"page":"2677-2686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical characteristics and risk factors of arrhythmia during follow\u2010up of patients with idiopathic ventricular fibrillation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-1046","authenticated-orcid":false,"given":"Niels K.","family":"Stampe","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-9637","authenticated-orcid":false,"given":"Camilla B.","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-256X","authenticated-orcid":false,"given":"Charlotte","family":"Glinge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9316","authenticated-orcid":false,"given":"Jacob","family":"Tfelt\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Forensic Medicine, Faculty of Medical Sciences University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-4712","authenticated-orcid":false,"given":"Bo G.","family":"Winkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut272"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004258"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz151"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853143"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2019.06.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12737"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz221"},{"issue":"36","key":"e_1_2_7_9_1","first-page":"2793","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"2015","author":"Priori SG","journal-title":"Eur Heart 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