{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:53:30Z","timestamp":1784796810475,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008810","name":"NSW Ministry of Health","doi-asserted-by":"publisher","award":["Early\u2010Mid Career Fellowship"],"award-info":[{"award-number":["Early\u2010Mid Career Fellowship"]}],"id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Testing for inducible ventricular tachycardia (VT) pre\u2010 and postablation forms the cornerstone of contemporary scar\u2010related VT ablation procedures. There is significant heterogeneity in reported VT induction protocols. We examined the utility of an extensive induction protocol (up to 4 extra\u2010stimuli [ES]\u2009\u00b1\u2009burst ventricular pacing) compared to the current guideline\u2010recommended protocol (up to 3ES, defined as limited induction protocol) in patients with scar\u2010related VT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Sixty\u2010two patients (age: 64\u2009\u00b1\u200914 years; left ventricular ejection fraction: 37\u2009\u00b1\u200913%, ischemic cardiomyopathy: 31, nonischemic cardiomyopathy: 31) with at least one inducible VT were included. An extensive testing protocol induced 11%\u201317% more VTs, compared to the limited induction protocol before, and after the final ablation. VT recurred in 48% of patients during a mean follow up of 566\u2009\u00b1\u2009428 days. Patients who were noninducible for <jats:italic>any<\/jats:italic> VT using the limited induction protocol had worse ventricular arrhythmia (VA)\u2010free survival (12 months, 43% vs. 82%; <jats:italic>p<\/jats:italic>\u2009=\u2009.03) and worse survival free of VA, transplantation and mortality (12 months 46% vs. 82%; <jats:italic>p<\/jats:italic>\u2009=\u2009.02), compared to patients who were noninducible for <jats:italic>any<\/jats:italic> VT using the extensive induction protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Between 11% and 17% of inducible VTs may be missed if 4ES and burst pacing are not performed in induction protocols before and after ablation. Noninducibility for <jats:italic>any VT<\/jats:italic> after an extensive induction protocol after the final ablation portends more favorable prognostic outcomes when compared with the current guideline\u2010recommended induction protocol of up to 3ES. This data suggests that the adoption of an extensive induction protocol is of prognostic benefit after VT ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14740","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T22:18:49Z","timestamp":1600294729000},"page":"2909-2919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic significance of extensive versus limited induction protocol during catheter ablation of scar\u2010related ventricular tachycardia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-7741","authenticated-orcid":false,"given":"Timothy","family":"Campbell","sequence":"first","affiliation":[{"name":"Department of Cardiology Westmead Hospital  Sydney Australia"},{"name":"Westmead Applied Research Centre University of Sydney  Sydney New South Wales 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