{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:32Z","timestamp":1787015372802,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ablation of septal substrate\u2010associated ventricular tachycardia (VT) in patients with nonischemic cardiomyopathy (NICM) is challenging. We sought to standardize the characterization of septal substrates on late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) and to examine the association of that substrate with VT exit and isthmus sites on invasive mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      LGE\u2010CMR was performed before electroanatomic mapping\u00a0and ablation for VT in 20 NICM patients. LGE extent and distribution were quantified using myocardial signal\u2010intensity\n                      <jats:italic>Z<\/jats:italic>\n                      scores (SI\u2010Z). The SI\u2010Z thresholds correlating to previously validated voltage thresholds, for abnormal tissue and dense scar were defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bipolar and unipolar (electrogram) voltage amplitude measurements from the LV and RV were negatively associated with SI\u2010Z from LGE\u2010CMR imaging (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). SI\u2010Z thresholds for appropriate CMR identification of septal substrates were determined to be greater than\u00a0\u2212.15 for border zone and greater than\u2009.03 for a dense scar. Among all patients, 34 critical VT sites were identified with SI\u2010Z distribution in the range of \u2212.97 to\u2009.06. Thirty (88.2%) critical sites were located in the dense LGE, 1 (2.9%) in the border zone, and 3 (8.9%) in healthy tissue but within 7\u2009mm of LGE. Of note, critical VT sites were all located at the basal septum close to valves (distance to aortic valve: 17.5\u2009\u00b1\u200931.2\u2009mm, mitral valve: 21.2\u2009\u00b1\u20098.7\u2009mm) in nonsarcoidosis cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Critical sites of septal VT in NICM patients are predominantly in the CMR defined dense scar when using standardized signal\u2010intensity thresholds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.14777","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T04:00:55Z","timestamp":1602993655000},"page":"3262-3276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of septal late gadolinium enhancement on cardiac magnetic resonance with ventricular tachycardia ablation targets in nonischemic cardiomyopathy"],"prefix":"10.1111","volume":"31","author":[{"given":"Ling","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Medicine, Heart Rhythm Center Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine  Taipei Taiwan"},{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-8899","authenticated-orcid":false,"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4857","authenticated-orcid":false,"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":false,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-6149","authenticated-orcid":false,"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Zado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Desjardins","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-0259","authenticated-orcid":false,"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Cardiology and Electrophysiology Section University of Pennsylvania Philadelphia Pennsylvania 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