{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:26:42Z","timestamp":1792657602552,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Activation from an automatic focus is thought to show centrifugal spread. In patients with premature ventricular complex\/ventricular tachycardia (PVC\/VT) from the right ventricular outflow tract (RVOT), the presence of preferential conduction and epicardial connections could however also lead to noncentrifugal wavefront propagation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study endocardial activation in RVOT PVC\/VT using high\u2010resolution 3D activation mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with frequent idiopathic PVC\/VT were studied. High\u2010resolution 3D activation maps were acquired using a multielectrode mapping catheter (Orion, Rhythmia, Boston Scientific). Noncentrifugal activation was defined as a pattern of wavefront propagation which does not show uniform propagation in all directions from one focus. Patients without sustained ablation success and patients with a left\u2010sided PVC origin or with insufficient map density were excluded from the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients (44% female) with a median age of 54 years (interquartile range [IQR], 47\u201364) and a median PVC burden of 19% (IQR, 15\u201327) were studied. High\u2010resolution activation maps consisting of a median number of 1863 mapping points (IQR, 1195\u20132463 points) demonstrated a centrifugal activation in 6\/16 (38%) and a noncentrifugal activation in 10\/16 (62%). When comparing patients with centrifugal and noncentrifugal activation, patients with centrifugal activation were older (<jats:italic>p<\/jats:italic>\u2009=\u2009.01), but no differences were found in age, gender, QRS duration of the PVC's and sites of origin in the RVOT. No procedural complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010resolution multielectrode mapping demonstrates the presence of noncentrifugal activation patterns in some of the patients with idiopathic RVOT PVC\/VT. This may indicate the presence of preferential conduction and or epicardial\/intramural connections in the outflow tract.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14796","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T12:04:24Z","timestamp":1603973064000},"page":"102-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Noncentrifugal activation patterns in focal RVOT PVC\/VT: New insights from high density multielectrode mapping"],"prefix":"10.1111","volume":"32","author":[{"given":"Justin","family":"Ng","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Chhachhi","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stobie","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arieh","family":"Keren","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Popal","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":false,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","first-page":"1143","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias","volume":"21","author":"Cronin EM","year":"2019","journal-title":"Heart Rhythm"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-011-0201-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.10.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv421"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.11.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.12.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.09.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.969592"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13856"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.077875"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.043"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.11.027"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T22:30:47Z","timestamp":1692657047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jce.14796"],"URL":"https:\/\/doi.org\/10.1111\/jce.14796","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"2020-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}