{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:20:32Z","timestamp":1755598832866,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients with sinus node disease (SND), the dual\u2010chamber pacemaker (PM) is programmed in DDDR mode with an algorithm to avoid unnecessary right ventricular (RV) pacing. This pacing mode may prolong PR interval with consequently atrioventricular (AV) asynchrony which is associated with a higher risk of atrial fibrillation (AF). We evaluate whether preserving AV synchrony by setting a fixed AV delay during physiological RV pacing, that is,\u00a0His bundle pacing (HBP), could reduce the risk of AF occurrence in comparison with a standard pacing mode with an algorithm to avoid unnecessary RV pacing (DDD\u2010VPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We collected retrospective data from 313 consecutive patients who had undergone PM for SND. The first occurrence of persistent AF (&gt;7 consecutive days) as a function of the pacing mode was evaluated. HBP and DDD\u2010VPA were implemented in 82 and 231 patients, respectively. Persistent AF occurred in 128 (40.9%) patients over a median follow\u2010up of 70 months (67\u2013105). The DDD\u2010VPA pacing mode was significantly correlated with the occurrence of persistent AF only when the basal PR was long (&gt;180 ms). The risk of persistent AF was significantly lower in patients on HBP than in those on DDD\u2010VPA, adjusted HR\u2009=\u2009.57 (95% CI,\u2009.36\u2013\u2009.89, <jats:italic>p<\/jats:italic>=.014). Other independent predictors of persistent AF occurrence were: A history of AF (HR\u2009=\u20093.91; 95% CI, 2.48\u20136.19, <jats:italic>p<\/jats:italic>\u2009=\u2009.001), age, and long PR interval (HR\u2009=\u20092.98; 95% CI, 2.00\u20134.43, <jats:italic>p<\/jats:italic>=.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In SND patients and long basal PR interval, the HBP may reduce the risk of persistent AF in comparison with the DDD\u2010VPA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14810","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T04:39:45Z","timestamp":1605155985000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Occurrence of persistent atrial fibrillation during pacing for sinus node disease: The influence of His bundle pacing versus managed ventricular pacing"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4040-3838","authenticated-orcid":false,"given":"Gianni","family":"Pastore","sequence":"first","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Marcantoni","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Lanza","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Maines","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rovereto General Hospital  Rovereto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Noventa","sequence":"additional","affiliation":[{"name":"Departments of Molecular Medicine University of Padua  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Corbucci","sequence":"additional","affiliation":[{"name":"Value\u2010Based MKtg Director Boston Scientific Italy  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Baracca","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loris","family":"Roncon","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-3918","authenticated-orcid":false,"given":"Francesco","family":"Zanon","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit, Department of Cardiology Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071880"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072769.17295.B1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.12.075"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut436"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv268"},{"key":"e_1_2_7_8_1","first-page":"282","article-title":"Reduction in unnecessary ventricular pacing fails to affect hard clinical outcomes in patients with preserved left ventricular function: a meta\u2010analysis","volume":"19","author":"Shurrab 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