{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:36:22Z","timestamp":1772120182900,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to validate the performance of the VT\u2010LVAD risk model in predicting late ventricular arrhythmias (VAs) in patients after left ventricular assist device (LVAD) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The need for implantable cardioverter\u2010defibrillator (ICD)\u2010implantation in LVAD recipients is not well studied. A better selection of the patients with high risk for late VAs could lead to a more targeted ICD\u2010implantation or replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study evaluated the performance of the VT\u2010LVAD prognostic score (VAs prior LVAD, no ACE\u2010inhibitor in medication, heart failure duration\u2009&gt;\u200912 months, early VAs post\u2010LVAD implantation, atrial fibrillation prior LVAD, idiopathic dilated cardiomyopathy) for the endpoint of the occurrence of late VAs in 357 LVAD patients in Heart Centre of Leipzig.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the initial 460 patients, 357 (age: 58\u2009\u00b1\u200910 years; left ventricular ejection fraction: 20\u2009\u00b1\u20096%; HeartWare: 50%; HeartMate III: 42%) were assigned to four risk groups according to their VT\u2010LVAD score varying from low risk to very high risk. After 25 months, late VAs occurred in 130 patients. The VT\u2010LVAD score was an independent predictor of late VAs (multivariate analysis; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;\u2009.001; goodness\u2010of\u2010tip <jats:italic>p<\/jats:italic>\u2009=\u2009.347; odds ratio: 4.8). While there was no statistically significant difference between the low\u2010 and intermediate\u2010risk group, risk stratification for patients with high risk and very high risk performed more accurately (pairwise comparison <jats:italic>p<\/jats:italic>\u2009=\u2009.005 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The VT\u2010LVAD score predicted accurately the occurrence of late VAs in high\u2010risk LVAD recipients in a large external cohort of LVAD recipients supporting its utility for more targeted ICD implantations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14827","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T14:59:48Z","timestamp":1607007588000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Validation of the VT\u2010LVAD score for prediction of late VAs in LVAD recipients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-2775","authenticated-orcid":false,"given":"Angeliki","family":"Darma","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology Heart Centre of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Heart Centre of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Heart Centre of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals of Coventry and Warwickshire  Coventry 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P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Service de Cardiologie et Maladies Vasculaires, CHU Rennes  Rennes France"},{"name":"Department of Cardiologie Universit\u00e9 de Rennes 1  Rennes France"},{"name":"Research Department U1099, INSERM  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Service de Cardiologie et Maladies Vasculaires, CHU Rennes  Rennes France"},{"name":"Department of Cardiologie Universit\u00e9 de Rennes 1  Rennes France"},{"name":"Research Department U1099, INSERM  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Galand","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Service de Cardiologie et Maladies Vasculaires, CHU Rennes  Rennes 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