{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:29:56Z","timestamp":1762918196490,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long QT syndrome (LQTS) is a dangerous arrhythmia disorder that often presents in childhood and adolescence. The exercise stress test (EST) and QT\u2010stand test may unmask QT interval prolongation at key heart rate transition points in LQTS, but their utility in children is debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if the QT\u2010stand test or EST can differentiate children with a low probability of LQTS from those with confirmed LQTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study compares the corrected QT intervals (QTc) of children (&lt;19 years) during the QT\u2010stand test and EST. Patients were divided into three groups for comparison: confirmed LQTS (<jats:italic>n<\/jats:italic>\u2009=\u200914), low probability of LQTS (<jats:italic>n<\/jats:italic>\u2009=\u200914), and a control population (<jats:italic>n<\/jats:italic>\u2009=\u20099).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the Bazett formula, confirmed LQTS patients had longer QTc intervals than controls when supine, standing, and at 3\u20134\u2009min of recovery (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.01). Patients with a low probability of LQTS had longer QTc duration upon standing (<jats:italic>p<\/jats:italic>\u2009=\u2009.018) and at 1\u2009min of recovery (<jats:italic>p<\/jats:italic>\u2009=\u2009.016) versus controls. There were no significant QTc differences at any transition point between low probability and confirmed LQTS. Using the Fridericia formula, differences in QTc between low probability and confirmed LQTS were also absent at the transition points examined, except at 1\u2009min into exercise, where low probability patients had shorter QTc intervals (437 vs. 460\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic utility of the QT stand test and EST remains\u00a0unclear in pediatric LQTS. The formula used for heart rate correction may influence accuracy, and dynamic T\u2013U wave morphology changes may confound interpretation in low probability situations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14865","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T16:19:20Z","timestamp":1609431560000},"page":"500-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Potential overdiagnosis of long QT syndrome using exercise stress and QT stand testing in children and adolescents with a low probability of disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-4377","authenticated-orcid":false,"given":"Thomas M.","family":"Roston","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology British Columbia Children's Hospital and The University of British Columbia Vancouver 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn R.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology British Columbia Children's Hospital and The University of British Columbia Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-7400","authenticated-orcid":false,"given":"Shubhayan","family":"Sanatani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology British Columbia Children's Hospital and The University of British Columbia Vancouver 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