{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:30:05Z","timestamp":1772166605446,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In previous studies, patients undergoing ablation of ganglionated plexi (GPA) for vagally mediated bradyarrhythmias were noted to have shortening of their corrected QT interval (QTc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the effects of GPA (group 1) to pulmonary vein isolation + GPA (group 2) on QTc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We enrolled 39 patients, n = 25 in group 1 and n = 14 in group 2. QTc was calculated at baseline, at 24 h after ablation, and at 9\u201012 months in the follow\u2010up. Recurrent syncope, asystole &gt;2 s, and\/or second\u2010 or third\u2010degree AVB episodes were carefully documented as the primary outcome in group 1. Any atrial arrhythmia \u226530 seconds documented on 24\u2010h Holter monitoring was defined as the primary outcome in group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up time was 14.9 \u00b1 4 months. Acute success was achieved in all cases. In whole cohort, a significant shortening on QTcBazett, QTcFramingham, QTcFredericia, and QTcHodges was observed [416 vs 398ms (p = .002), 411vs 378 ms (p\u2009&lt;\u2009.001), 412 vs 379ms (p\u2009&lt;\u2009.001), and 420 vs 383ms (p\u2009&lt;\u2009.001), respectively]. In the linear mixed model analysis, the longitudinal reduction tendency in the QTc level was more pronounced in group 1. Event\u2010free survival was detected in 90.7% (59\/65) of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results demonstrate a significant shortening of QTc in addition to high medium\u2010term success rates after GPA. Pulmonary vein isolation + GPA was associated with lower QTc shortening effect which implies structural disease may change electrophysiological response to ablation. The most likely mechanism is the effect of GPA on the sympathetic system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14969","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T13:40:50Z","timestamp":1614174050000},"page":"1161-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["QTc shortening effect of ganglionated plexi ablation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8061-9660","authenticated-orcid":false,"given":"Tolga","family":"Aksu","sequence":"first","affiliation":[{"name":"Department of Cardiology Kocaeli Derince Training and Research Hospital University of Health Sciences Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Bozyel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kocaeli Derince Training and Research Hospital University of Health Sciences Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-0711","authenticated-orcid":false,"given":"Kivanc","family":"Yalin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim H.","family":"Tanboga","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nisantasi University &amp; Hisar Intercontinental Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-3687","authenticated-orcid":false,"given":"Rakesh","family":"Gopinathannair","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Kansas City Heart Rhythm Institute and Research Foundation Overland Park Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2004.10.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-020-00704-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.07.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-020-00831-w"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13912"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14625"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20000801)259:4<353::AID-AR10>3.0.CO;2-R"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(02)80005-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2014.08.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000799"},{"key":"e_1_2_6_13_1","first-page":"9","article-title":"The effect of sympathetic and parasympathetic activity on QT duration. Clinical study in patients with normal and prolonged QT time","volume":"31","author":"Solti F","year":"1989","journal-title":"Cor Vasa"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-005-0820-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12855"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008703"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:00:06Z","timestamp":1693332006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jce.14969"],"URL":"https:\/\/doi.org\/10.1111\/jce.14969","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}