{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:58:49Z","timestamp":1790503129543,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Vidi\/grant number 91717339"],"award-info":[{"award-number":["Vidi\/grant number 91717339"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","award":["ICD 783454"],"award-info":[{"award-number":["ICD 783454"]}],"id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Advancing age is a known risk factor for developing atrial fibrillation (AF), yet it is unknown which electrophysiological changes contribute to this increased susceptibility. The goal of this study is to investigate conduction disturbances and unipolar voltages (UV) related to aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 216 patients (182 male, age: 36\u201383 years) without a history of AF undergoing elective coronary artery bypass surgery. Five seconds of sinus rhythm were recorded intraoperatively at the right atrium (RA), Bachmann's bundle (BB), the left atrium and the pulmonary vein area (PVA). Conduction delay (CD), \u2010block (CB), \u2010velocity (CV), length of longest CB lines and UV were assessed in all regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With aging, increasing conduction disturbances were found, particularly at RA and BB (RA: longest CB line\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.158,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.021; BB: CB prevalence\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.206,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003; CV\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009\u2212.239,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0005). Prevalence of low UV areas (UV &lt;5th percentile) increased with aging at the BB and PVA (BB:\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.237,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0005 and PVA:\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009.228,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aging is accompanied by an increase in conduction disturbances during sinus rhythm and a higher prevalence of low UV areas, particularly at BB and in the RA. These electrophysiological alterations could in part explain the increasing susceptibility to AF development associated with aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.14978","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:07:56Z","timestamp":1614668876000},"page":"903-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Atrial electrophysiological characteristics of aging"],"prefix":"10.1111","volume":"32","author":[{"given":"Willemijn F.B.","family":"van der Does","sequence":"first","affiliation":[{"name":"Unit Translational Electrophysiology, Department of Cardiology Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Houck","sequence":"additional","affiliation":[{"name":"Unit Translational Electrophysiology, Department of Cardiology Erasmus Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Cardiothoracic surgery Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annejet","family":"Heida","sequence":"additional","affiliation":[{"name":"Unit Translational Electrophysiology, Department of Cardiology Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs S.","family":"van Schie","sequence":"additional","affiliation":[{"name":"Unit Translational Electrophysiology, Department of Cardiology Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank R.N.","family":"van Schaagen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic surgery Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick J.H.J.","family":"Taverne","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic surgery Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad J.J.C.","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic surgery Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja M.S.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Unit Translational Electrophysiology, Department of Cardiology Erasmus Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi825"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus333"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960260911"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.044"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00293.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.10.034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-016-9685-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003972"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.4.604"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000758"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.6.1221"},{"issue":"6","key":"e_1_2_8_15_1","first-page":"7","article-title":"Impact of ischemic and valvular heart disease on atrial excitation: a high\u2010resolution epicardial mapping study","author":"Mouws E","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933389"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1684"},{"key":"e_1_2_8_18_1","first-page":"27","article-title":"Age\u2010related atrial fibrosis. 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