{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:49:57Z","timestamp":1768258197652,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Non\u2010pulmonary vein (PV) triggers are a major cause of atrial tachyarrhythmia (ATA) recurrence after catheter ablation. However, the effect of the diagnosis\u2010to\u2010ablation time (DAT) on non\u2010PV triggers in persistent atrial fibrillation is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This observational study evaluated 502 consecutive persistent AF patients who underwent initial ablation. We compared 408 patients whose DAT was &lt;3 years with 94 patients whose DAT was\u00a0\u22653 years. Following PV and posterior wall isolation, 193 non\u2010PV triggers, including 50 AFs, 30 atrial tachycardias (ATs), and 113 repetitive atrial premature beats, were elicited and ablated in 137 (27%) patients. Specifically, 80 non\u2010PV AF\/AT triggers were provoked in 64 (13%) patients, being identified more frequently in the DAT\u2009\u2265\u20093 years group than in the DAT\u2009&lt;\u20093 years group (20% vs. 11%, <jats:italic>p<\/jats:italic>\u2009=\u2009.025) especially with a higher prevalence of coronary sinus\/inferior left atrial triggers. During a median follow\u2010up of 770 days, the ATA recurrence\u2010free rate was higher in the DAT\u2009&lt;\u20093 years group than the DAT\u2009\u2265\u20093 years group (79% vs. 53% at 2 years, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In a multivariate analysis, female sex (odds ratio: 2.70, <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and a longer DAT (odds ratio: 1.13\/year, <jats:italic>p<\/jats:italic>\u2009=\u2009.008) were predictors of non\u2010PV AF\/AT triggers, and a longer DAT (hazard ratio: 1.12\/year, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and non\u2010PV AT\/AF triggers (hazard ratio: 1.79, <jats:italic>p<\/jats:italic>\u2009=\u2009.009) were associated with ATA recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early ablation after the first diagnosis of persistent AF may reduce emerging non\u2010PV AF\/AT triggers and ATA recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15002","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T17:56:50Z","timestamp":1615658210000},"page":"1251-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Impact of diagnosis\u2010to\u2010ablation time on non\u2010pulmonary vein triggers and ablation outcomes in persistent atrial fibrillation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-2332","authenticated-orcid":false,"given":"Tomomasa","family":"Takamiya","sequence":"first","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-3786","authenticated-orcid":false,"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-2613","authenticated-orcid":false,"given":"Yukihiro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikenouchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama 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