{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:40:40Z","timestamp":1778503240531,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010compaction cardiomyopathy (NCCM) is a form of structural heart disease prone to ventricular arrhythmias (VAs) and sudden cardiac death. Non\u2010compacted myocardium may harbor VA substrate, though some reports suggest otherwise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to characterize the electrophysiologic (EP) features of VA in NCCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review of case reports, case series, and observational studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty\u2010five cases of NCCM from studies between 2000 and 2020 were included. Mean age was 34\u2009\u00b1\u200920 years, mean left ventricular (LV) ejection fraction was 42\u2009\u00b1\u200915% with two cases having late gadolinium enhancement on magnetic resonance imaging. The LV apex was the most common non\u2010compacted segment (86%); 10% involved the right ventricle (RV). Antiarrhythmic failure was documented in 16 cases, of which 50% failed more than one agent. Only 23% of monomorphic VAs localized to regions of non\u2010compaction on electrocardiogram. Most frequently, VAs localized to the RV outflow tract\u00a0(<jats:italic>n<\/jats:italic>\u2009=\u200921), posterior fascicle (<jats:italic>n<\/jats:italic>\u2009=\u200919), and anterolateral LV apex (<jats:italic>n<\/jats:italic>\u2009=\u20099). All cases with apical exits arose from the non\u2010compacted myocardium. On EPS, 83% of sustained VTs were due to re\u2010entry, 17% due to focal mechanism. Catheter ablation was performed in 39 cases, with 7 requiring more than 1 procedure. Acute VA non\u2010inducibility was achieved in 82% and VA\u2010free survival was reported in 85% over a mean follow\u2010up of 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of VAs in NCCM arise remotely\u00a0from non\u2010compacted myocardium, and non\u2010re\u2010entrant mechanism seen in ~1\/5th of sustained VTs. Catheter ablation outcomes appear favorable. Further study is needed to understand the pathophysiology of VA in NCCM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15026","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:01:42Z","timestamp":1617274902000},"page":"1421-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Electrophysiologic and electroanatomic characterization of ventricular arrhythmias in non\u2010compaction cardiomyopathy: A systematic review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-5618","authenticated-orcid":false,"given":"Ashwin","family":"Bhaskaran","sequence":"first","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"},{"name":"University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-7741","authenticated-orcid":false,"given":"Timothy","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"},{"name":"Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohaib","family":"Virk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-3993","authenticated-orcid":false,"given":"Richard G.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"},{"name":"Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy","family":"Kizana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"},{"name":"Westmead Institute for Medical Research Westmead Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-5076","authenticated-orcid":false,"given":"Saurabh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westmead Hospital Sydney NSW Australia"},{"name":"Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174287"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132478.60674.D0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00755-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.05.039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61282-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064677"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01015.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12394"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.11.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.6.666"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.045"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.07.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/72.1.26"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz317"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2015.03.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00170-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.08.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002511"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.2.507"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793176518"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi025"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2008.40"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:11:58Z","timestamp":1693617118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/jce.15026"],"URL":"https:\/\/doi.org\/10.1111\/jce.15026","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"assertion":[{"value":"2020-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}