{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:58:32Z","timestamp":1794031112524,"version":"4.8.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contrast computed tomography (CT) is a useful tool for the detection of intracardiac thrombi. We aimed to assess the accuracy of the late\u2010phase prone\u2010position contrast CT (late\u2010pCT) for thrombus detection in patients with persistent or long\u2010standing persistent atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Early and late\u2010phase pCT were performed in 300 patients with persistent or long\u2010standing AF. If late\u2010pCT did not show an intracardiac contrast defect (CD), catheter ablation (CA) was performed. Immediately before CA, intracardiac echocardiography (ICE) from the left atrium was performed to confirm thrombus absence and the estimation of the blood velocity of the left atrial appendage (LAA). For patients with CDs on late\u2010pCT, CA performance was delayed, and late\u2010pCT was performed again after several months following oral anticoagulant alterations or dosage increases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 40 patients who exhibited CDs in the early phase of pCT, six showed persistent CDs on late\u2010pCT. In the remaining 294 patients without CDs on late\u2010pCT, the absence of a thrombus was confirmed by ICE during CA. In all six patients with CD\u2010positivity on late\u2010pCT, the CDs vanished under the same CT conditions after subsequent anticoagulation therapy, and CA was successfully performed. Furthermore, the presence of residual contrast medium in the LAA on late\u2010pCT suggested a decreased blood velocity in the LAA (\u2009\u2264\u200915\u2009cm\/s) (sensitivity\u2009=\u20090.900 and specificity\u2009=\u20090.621).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Late\u2010pCT is a valuable tool for the assessment of intracardiac thrombi and LAA dysfunction in patients with persistent or long\u2010standing persistent AF before CA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15062","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T03:31:30Z","timestamp":1620617490000},"page":"1803-1811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prone\u2010position computed tomography in the late phase for detecting intracardiac thrombi in the left atrial appendage before catheter ablation for atrial fibrillation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-6426","authenticated-orcid":false,"given":"Rena","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Cardiology Japan Red Cross Yokohama City Bay Hospital  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japan Red Cross Yokohama City Bay Hospital  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3413-2629","authenticated-orcid":false,"given":"Shinichi","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japan Red Cross Yokohama City Bay Hospital  Yokohama Kanagawa 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