{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:55Z","timestamp":1740137155176,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The local conduction delay has been deemed to play an important role in the perpetuation of ventricular fibrillation (VF) in Brugada syndrome (BrS). We evaluated the relationship between the activation delay during programmed stimulation and cardiac events in BrS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 47 consecutive BrS patients who underwent an electrophysiological study and received implantable cardiac defibrillator therapy. We divided the patients into two groups based on whether they had developed VF (11 patients) or not (36 patients) during the follow\u2010up period of 89\u2009\u00b1\u200953 months. The activation delay was assessed using the interval between the stimulus and the QRS onset during programmed stimulation. The mean increase in delay (MID) was used to characterize the conduction curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MID at the right ventricular outflow tract (RVOT) was significantly greater in patients with VF (4.5\u2009\u00b1\u20091.2\u2009ms) than in those without VF (2.2\u2009\u00b1\u20090.9\u2009ms) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). A receiver operating characteristics curve analysis indicated that the optimal cut\u2010off point for discriminating VF occurrence was 3.3 with 88.9% sensitivity and 91.3% specificity. Furthermore, patients with an MID at the RVOT\u2009\u2265\u20093.3\u2009ms showed significantly higher rates of VF recurrence than those with an MID at the RVOT\u2009&lt;\u20093.3\u2009ms (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The clinical characteristics, including the signal\u2010averaged electrocardiogram measurement and VF inducibility were similar between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A prolonged MID at the RVOT was associated with VF and maybe an additional electrophysiological risk factor for VF in BrS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15065","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:00:10Z","timestamp":1619758810000},"page":"1939-1946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progressive increase in activation delay during premature stimulation is related to ventricular fibrillation in Brugada syndrome"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-1056","authenticated-orcid":false,"given":"Yuki","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ikami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata 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