{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:33:35Z","timestamp":1789544015121,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ablation of ventricular arrhythmias (VA) originating from the left ventricular (LV) papillary muscles (PM) has the potential to damage the mitral valve apparatus resulting in mitral regurgitation (MR). This study sought to evaluate the effect of radiofrequency (RF) ablation of a PM on MR severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with pre\u2010 and postablation transthoracic echocardiograms who underwent PM ablation for treatment of VA were retrospectively identified and compared to similar patients who underwent VA ablation at non\u2010PM sites. MR severity was evaluated pre\u2010 and postablation in both groups and graded as none\/trace (Grade 0); mild\/mild\u2010to\u2010moderate (Grade 1); moderate (Grade 2); moderate\u2010to\u2010severe\/severe (Grade 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 and 49 patients were included in the PM and non\u2010PM groups, respectively. There were no significant baseline demographic differences. The PM group had longer RF ablation times (22.3 vs. 13.3\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) compared to the non\u2010PM group. Most patients had low\u2010grade MR in both groups at baseline. Change in pre\u2010 versus postablation MR within the PM group was not statistically significant by Wilcoxon rank\u2010sum test (Figure\u00a02, <jats:italic>p<\/jats:italic>\u2009=\u2009.46). MR severity following ablation was also evaluated using logistic regression models. The odds ratio for worsening MR in the PM group compared to non\u2010PM was 0.19 (95% confidence interval: 0.008\u20134.18, <jats:italic>p<\/jats:italic>\u2009=\u2009.29) after adjusting for comorbidities, LV ejection fraction, and LV internal end\u2010diastolic diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RF ablation of VA originating from PM under intracardiac echocardiography guidance did not result in clinically or statistically significant worsening of MR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15104","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T13:19:32Z","timestamp":1621171172000},"page":"1931-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of catheter ablation for ventricular arrhythmias originating from the left ventricular papillary muscles on mitral valve function"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-638X","authenticated-orcid":false,"given":"Joshua","family":"Sink","sequence":"first","affiliation":[{"name":"Stritch School of Medicine Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Turin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cytron","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samip","family":"Vasaiwala","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maine Medical Center  Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smit","family":"Vasaiwala","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loyola University Medical Center  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.04.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12478"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.06.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002711"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"351","article-title":"Mitral valve perforation appearing years after radiofrequency ablation","volume":"20","author":"Fisch\u2010Thomsen M","year":"2011","journal-title":"J Heart Valve 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