{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:21:39Z","timestamp":1790720499528,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Local impedance (LI) drop measured with microfidelity electrodes embedded in the tip of an ablation catheter accurately reflects tissue heating during radiofrequency (RF) ablation. Previous studies found 15\u201330\u2009\u2126 LI drops created successful lesions, while more than 40\u2009\u2126 drops were associated with steam pops. The objective of this study was to evaluate the safety and efficacy of LI\u2010guided ablation using standard (30\u2009W) and high\u2010power (50\u2009W) in a preclinical model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RF lesions were created in explanted swine hearts (<jats:italic>n<\/jats:italic>\u2009=\u20096) to assess the feasibility of LI\u2010guided ablation by targeting 10, 20, or 30\u2009\u03a9 (<jats:italic>n<\/jats:italic>\u2009=\u200920\/group) drops. Subsequently, LI\u2010guided ablation was evaluated in a chronic animal model (<jats:italic>n<\/jats:italic>\u2009=\u20098 Canines, 25\u201329\u2009kg, 30\/50\u2009W). During the index procedure point\u2010by\u2010point intercaval line ablation and left inferior pulmonary vein (PV) isolation were performed. RF duration was at the operators\u2019 discretion but discontinued early if a 15\u201330\u2009\u03a9 drop was achieved. Operators attempted to avoid LI drops of more than 40\u2009\u03a9. At 1\u2010month, durable conduction block was evaluated with electroanatomic mapping followed by necropsy and histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In explanted tissue, terminating ablation at 10, 20, or 30\u2009\u03a9 LI drops created statistically larger lesions (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05; 1.8 [1.6\u20132.4]\u2009mm, 3.3 [3.0\u20133.7]\u2009mm; 4.9 [4.3\u20135.5]\u2009mm). LI\u2010guided high\u2010power ablation in vivo significantly reduced RF duration per application compared to standard\u2010power (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05; intercaval: 8.9\u2009\u00b1\u20095.2 vs. 18.1\u2009\u00b1\u200911.0\u2009s, PV: 9.6\u2009\u00b1\u20095.4 vs. 23.2\u2009\u00b1\u200910.3\u2009s). LI drops of 15\u201340\u2009\u03a9 were more readily achievable for high\u2010power (90.1%, 318\/353) than standard\u2010power (71.7%, 243\/339). All intercaval lines and PV isolations were durable (16\/16) at 1\u2010month. Necropsy revealed no major collateral injury to the pericardium, phrenic nerve, esophagus, or lungs. There was no pericardial effusion, stroke, tamponade, or PV stenosis. Vagal nerve injury was found in two 30\u2009W animals after using 19.7\u2009\u00b1\u200913.9 and 19.5\u2009\u00b1\u200911.8\u2009s RF applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LI\u2010guided ablation was found to be safe and efficacious in a chronic animal model. High\u2010power ablation more readily achieved more than 15\u2009\u03a9 drops, reduced RF duration compared with standard\u2010power, and had no major RF collateral injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15135","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T10:12:20Z","timestamp":1625479940000},"page":"2060-2068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Local impedance\u2010guided radiofrequency ablation with standard and high power: Results of a preclinical investigation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-0311","authenticated-orcid":false,"given":"Kofi","family":"Osei","sequence":"first","affiliation":[{"name":"Iowa Heart Center  West Des Moines Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Sulkin","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp.  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Hamann","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp.  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hughes","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp.  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Shuros","sequence":"additional","affiliation":[{"name":"Boston Scientific Corp.  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-4340","authenticated-orcid":false,"given":"Suraj","family":"Kapa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Meyers","sequence":"additional","affiliation":[{"name":"Iowa Heart Center  West Des Moines Iowa 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