{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:49:11Z","timestamp":1777679351997,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pacing at sites of late intraventricular activation (QLV) or long interventricular conduction (right ventricle [RV]\u2010left ventricular [LV]) have been associated with improved cardiac resynchronization therapy (CRT) outcomes. Quadripolar leads improve CRT outcomes by allowing for electrical repositioning to optimize pacing sites. However, little is known regarding the effect of such repositioning on electrical delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine the relationship between different electrical bipoles from a quadripolar lead and measures of electrical delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six patients underwent CRT with a quadripolar lead. The RV\u2010LV and QLV intervals were measured for both the proximal and distal bipoles and the difference (\u0394) between bipoles for each measure were calculated. Multivariate analyses were performed to identify predictors of electrical delays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This was a typical CRT population with a mean age of 65 years and ejection fraction of 27%, with left bundle branch block\u00a0(LBBB) present in 70%. The regression model for \u0394QLV was significant (<jats:italic>p<\/jats:italic>\u2009=\u2009.05), with both gender (<jats:italic>p<\/jats:italic>\u2009=\u2009.008) and LBBB status (<jats:italic>p<\/jats:italic>\u2009=\u2009.020) significant predictors. The overall regression model for \u0394RV\u2010LV was not significant. \u0394QLV and \u0394RV\u2010LV were significant among LBBB patients. Among non\u2010LBBB, only \u0394RV\u2010LV was significant (mean: 7.2\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.006). \u0394RV\u2010LV versus \u0394QLV were strongly correlated in LBBB (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.92) but not non\u2010LBBB (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In LBBB, \u0394RV\u2010LV and \u0394QLV are closely correlated suggesting that the proximal bipole and thus basal LV pacing sites should be selected when feasible. Greater variation in activation pattern is present in non\u2010LBBB, so pacing sites should be individualized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15156","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T14:14:30Z","timestamp":1625926470000},"page":"2498-2503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Electrical delays in quadripolar leads with cardiac resynchronization therapy"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-3607","authenticated-orcid":false,"given":"Scott M.","family":"Koerber","sequence":"first","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-9670","authenticated-orcid":false,"given":"Michael E.","family":"Field","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Cobb","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew J.","family":"Gregoski","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Sturdivant","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-0216","authenticated-orcid":false,"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441202"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_7_6_1","article-title":"Redefining the Classifications of Response to Cardiac Resynchronization Therapy: Results From the REVERSE Study","author":"Gold MR","year":"2021","journal-title":"J Am Coll Cardiol 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