{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:45:27Z","timestamp":1790423127702,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pacing\u2010induced cardiomyopathy (PICM) is a potential complication of chronic right ventricular (RV) pacing, but its characterization in adult patients is often complicated by pre\u2010existing cardiomyopathy. This study investigated the incidence of PICM in patients with congenital heart block (cHB) who have conduction disease from birth without confounding pre\u2010existing cardiac conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This retrospective cohort analysis included 42 patients with cHB and baseline left ventricular ejection fraction (LVEF)\u2009\u226550%. Kaplan\u2013Meier analysis was used to assess freedom from cardiomyopathy (defined as LVEF\u2009&lt;50%) between paced and nonpaced patients. Patients were 26\u2009\u00b1\u20093 years old at first presentation, 64% were women and baseline LVEF was 60.0\u2009\u00b1\u20090.2%. Median follow\u2010up from birth was 35 (interquartile range [IQR]: 20\u201342) years with a median of 6.7 years (IQR: 3.6\u20139.2) at our institution. Thirty\u2010two patients received pacing at mean age 21\u2009\u00b1\u20093 years. Patients receiving a pacemaker (PM) were significantly more likely to develop a cardiomyopathy (<jats:italic>p<\/jats:italic>\u2009=\u2009.021) and no patient developed a cardiomyopathy in the absence of a PM. Four patients who developed a new cardiomyopathy were upgraded to biventricular pacing, leading to stabilization or improvement of LVEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a relatively young and healthy cHB cohort, RV pacing is associated with a higher risk of developing a cardiomyopathy. These data confirm the deleterious effects of RV pacing on myocardial function in patients without pre\u2010existing structural cardiac disease and has clinical implications to the management of patients with cHB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15207","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T03:25:18Z","timestamp":1629343518000},"page":"2684-2689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ventricular pacing and myocardial function in patient with congenital heart block"],"prefix":"10.1111","volume":"32","author":[{"given":"Gautam","family":"Rangavajla","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Mulukutla","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floyd","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kancharla","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bhonsale","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-7247","authenticated-orcid":false,"given":"N. 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Mark","family":"Estes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-370X","authenticated-orcid":false,"given":"Sandeep K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-803X","authenticated-orcid":false,"given":"Samir","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14277"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.040"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Pacing\u2010associated cardiomyopathy in adult congenital heart disease","volume":"7","author":"Moore BM","year":"2020","journal-title":"Open Hear"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1459"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01048-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01302-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.08.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.044"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.02.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.096"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03481.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2020.110205"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.06.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300197"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:30:45Z","timestamp":1692991845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jce.15207"],"URL":"https:\/\/doi.org\/10.1111\/jce.15207","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]},"assertion":[{"value":"2021-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}