{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:14:31Z","timestamp":1781216071670,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Combined ablation and left atrial appendage closure (LAAC) is an alternative for atrial fibrillation patients with a high risk of stroke. However, the long\u2010term outcomes of this combined procedure remain elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from the establishment of databases to 1 January 2021. Studies on the long\u2010term (defined as a mean follow\u2010up of approximately 12 months or longer) efficacy and safety outcomes of combined ablation and LAAC were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 studies comprising 1428 patients were enrolled. The pooled long\u2010term freedom rate from atrial arrhythmia was 0.66 (95% confidence interval [CI]: 0.59\u20130.71), long\u2010term successful rate sealing of LAAC was 1.00 (95% CI: 1.00\u20131.00), and ischemic stroke\/transient ischemic attack\/systemic embolism during follow\u2010up was 0.01 (95% CI: 0.00\u20130.02). Meanwhile, of the periprocedural adverse events, phrenic nerve palsy, intracoronary air embolus, device embolization, and periprocedural death had a rate of 0.00 (95% CI: 0.00\u20130.00), procedure\u2010related bleeding events of 0.03 (95% CI: 0.02\u20130.04), and pericardial effusion requiring or not requiring intervention of 0.00 (95% CI: 0.00\u20130.01). Moreover, for the long\u2010term adverse events, device dislocation, intracranial bleeding, pericardial effusion requiring or not requiring intervention, and all\u2010cause mortality had a rate of 0.00 (95% CI: 0.00\u20130.00), device embolization of 0.01 (95% CI: 0.00\u20130.01), and other bleeding events of 0.01 (95% CI: 0.00\u20130.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis suggests that the combined atrial ablation and LAAC is an effective and safe strategy with long\u2010term benefits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15230","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T04:35:37Z","timestamp":1630125337000},"page":"3068-3081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The long\u2010term efficacy and safety of combining ablation and left atrial appendage closure: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Feng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital Affiliated to Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-5387","authenticated-orcid":false,"given":"Jin\u2010Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Da","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital Affiliated to Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Feng","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation Wuxi Tongren Rehabilitation Hospital Affiliated to Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-5048","authenticated-orcid":false,"given":"Ru\u2010Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuxi People's Hospital Affiliated to Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-314898"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027275"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-06981-3"},{"key":"e_1_2_9_8_1","first-page":"408","article-title":"Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non\u2010valvular atrial fibrillation","volume":"15","author":"Zhan XZ","year":"2018","journal-title":"J Geriatr Cardiol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.080"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-017-0257-x"},{"key":"e_1_2_9_11_1","first-page":"4","article-title":"Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies","volume":"19","author":"Tzikas A","year":"2017","journal-title":"Europace"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux183"},{"issue":"10","key":"e_1_2_9_13_1","first-page":"1397","article-title":"EHRA\/EAPCI expert consensus statement on catheter\u2010based left atrial appendage occlusion\u2014an update","volume":"16","author":"Glikson M","year":"2019","journal-title":"Europace"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8615410"},{"key":"e_1_2_9_15_1","first-page":"842","article-title":"[Feasibility and perioperative safety of the combined procedure of catheter ablation and watchman left atrial appendage closure]","volume":"48","author":"QS","year":"2020","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1123-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13845"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-070"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv037"},{"key":"e_1_2_9_21_1","first-page":"687","article-title":"Combined catheter ablation for atrial fibrillation and watchman? Left atrial appendage occlusion procedures: a single centre experience","volume":"5","author":"Walker DT","year":"2012","journal-title":"J Atr Fibrillation"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13250"},{"key":"e_1_2_9_23_1","first-page":"e3818","article-title":"Catheter ablation in combination with left atrial appendage closure for atrial fibrillation","volume":"72","author":"Swaans MJ","year":"2013","journal-title":"J Vis Exp"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy237"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13148"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05535-y"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.03.022"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy025"},{"key":"e_1_2_9_30_1","first-page":"225","article-title":"Combining left atrial appendage closure and catheter ablation for atrial fibrillation: 2\u2010year outcomes from a multinational registry","volume":"22","author":"Phillips KP","year":"2020","journal-title":"Europace"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.10.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-018-1312-4"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.07.009"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-019-04880-4"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv070"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13631"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6573296"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000855"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14084"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.002212"},{"key":"e_1_2_9_41_1","first-page":"2094","article-title":"Combination of catheter ablation for non\u2010valvular atrial fibrillation and left atrial appendage occlusion in a single procedure","volume":"16","author":"Li X","year":"2018","journal-title":"Exp Ther Med"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2015.11.001"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2029"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001182"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv730"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.076"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-019-09918-w"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017431.2020.1729399"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.15230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.15230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:31:05Z","timestamp":1693215065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.15230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,3]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jce.15230"],"URL":"https:\/\/doi.org\/10.1111\/jce.15230","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,3]]},"assertion":[{"value":"2021-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}