{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:57:54Z","timestamp":1790470674616,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Banting Postdoctoral Fellowship"],"award-info":[{"award-number":["Banting Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["10\u2010IAHU04\u2010LIRYC"],"award-info":[{"award-number":["10\u2010IAHU04\u2010LIRYC"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ventricular fibrillation (VF) is the main mechanism of sudden cardiac death in patients with hypertrophic cardiomyopathy (HCM). The origin of VF and the success of catheter ablation to eliminate recurrent episodes in this population are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>From 2010 to 2014, five patients with HCM (age 21\u2009\u00b1\u20099 years, three female) underwent invasive electrophysiological studies and ablation at our center after resuscitation from recurrent (9\u2009\u00b1\u20097) episodes of VF. Ventricular premature beats (VPBs), seen to initiate VF in certain cases, were recorded noninvasively before the ablation procedure. Postprocedural computed tomography (CT) was performed to correlate ablation sites with myocardial hypertrophy in three patients. Outcomes were assessed by clinical follow\u2010up and implantable cardioverter\u2010defibrillator interrogations. VPB triggers were localized invasively to the distal left Purkinje conduction system (left posterior fascicle [2], left anterior fascicle [1], and both fascicles [2]). All targeted VF triggers were successfully eliminated by radiofrequency ablation in the left ventricle. Among patients with postablation CT imaging, 93\u2009\u00b1\u200912% of ablation sites corresponded to hypertrophied segments. Over 50\u2009\u00b1\u200938 months, four of five patients were free from primary VF without antiarrhythmic drug therapy. One patient who had 13 episodes of VF before ablation had a single recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our study of patients with HCM and recurrent VF, VF was not initiated from the myocardium but rather from Purkinje arborization. These sources colocalized with the hypertrophic substrate, suggesting electromechanical interaction. Focal ablation at these sites was associated with a marked reduction in VF burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.15231","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:37:40Z","timestamp":1630111060000},"page":"2987-2994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Purkinje triggers of ventricular fibrillation in patients with hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"32","author":[{"given":"M\u00e9l\u00e8ze","family":"Hocini","sequence":"first","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut L\u00e9v\u00eaque Centre Hospitalier Universitaire de Bordeaux  Bordeaux\u2010Pessac France"},{"name":"L'Institut de Rythmologie et Mod\u00e9lisation Cardiaque (LIRYC)  Bordeaux\u2010Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-1652","authenticated-orcid":false,"given":"F. 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