{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:21:14Z","timestamp":1776867674523,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Quinidine is an effective therapy for a subset of polymorphic ventricular tachycardia and ventricular fibrillation (VF) syndromes; however, the efficacy of quinidine in scar\u2010related monomorphic ventricular tachycardia (MMVT) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Between 2009 and 2020 a single VT referral center, a total of 23 patients with MMVT and structural heart disease (age 66.7\u2009\u00b1\u200910.9, 20 males, 15 with ischemic cardiomyopathy, mean LVEF 22.2\u2009\u00b1\u200912.3%, 9 with left ventricular assist device [LVAD]) were treated with quinidine (14 quinidine gluconate; 996\u2009\u00b1\u2009321\u2009mg, 8 quinidine sulfate; 1062\u2009\u00b1\u2009588\u2009mg). Quinidine was used in combination with other antiarrhythmics (AAD) in 19 (13 also on amiodarone). All patients previously failed &gt;1 AAD (amiodarone 100%, mexiletine 73%, sotalol 32%, other 32%) and eight had prior ablations (median of 1.5). Quinidine was initiated in the setting of VT storm despite AADs (6), inability to tolerate other AADs (4), or recurrent VT(12). Ventricular arrhythmias recurred despite quinidine in 13 (59%) patients at a median of 26 (4\u2013240) days after quinidine initiation. In patients with recurrent MMVT, VT cycle length increased from 359 to 434\u2009ms (<jats:italic>p<\/jats:italic>\u2009=\u2009.02). Six (27.3%) patients remained on quinidine at 1 year with recurrence of ventricular arrhythmias in all. The following adverse effects were seen: gastrointestinal side effects (6), QT prolongation (2), rash (1), thrombocytopenia (1), neurologic side effects (1). One patient discontinued due to cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quinidine therapy has limited tolerability and long\u2010term efficacy when used in the management of amiodarone\u2010refractory scar\u2010related MMVT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15260","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T19:05:49Z","timestamp":1632942349000},"page":"3173-3178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and tolerability of quinidine as salvage therapy for monomorphic ventricular tachycardia in patients with structural heart disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-2844","authenticated-orcid":false,"given":"Amrish","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Larson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-5238","authenticated-orcid":false,"given":"Michael","family":"Ghannam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Saeed","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Cunnane","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Ghanbari","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Latchamsetty","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-8611","authenticated-orcid":false,"given":"Thomas","family":"Crawford","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krit","family":"Jongnarangsin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-6337","authenticated-orcid":false,"given":"Aman","family":"Chugh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Oral","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Morady","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-7282","authenticated-orcid":false,"given":"Frank","family":"Bogun","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Arrhythmia Service University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"issue":"15","key":"e_1_2_8_2_1","article-title":"AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"2018","author":"Al\u2010Khatib SM","year":"2017","journal-title":"Heart 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