{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:18:15Z","timestamp":1779142695215,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Single\u2010center observational studies have shown promising results with fragmented electrogram (FE)\u2010guided ganglionated plexus (GP) ablation in patients with vagally mediated bradyarrhythmia (VMB). We aimed to compare the acute procedural characteristics during FE\u2010guided GP ablation in patients with VMB performed by first\u2010time operators and those of a single high\u2010volume operator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This international multicenter cohort study included data collected over 2 years from 16 cardiac hospitals. The primary operators were classified according to their prior GP ablation experience: a single high\u2010volume operator who had performed\u2009&gt;\u200950 GP ablation procedures (Group 1), and operators performing their first GP ablation cases (Group 2). Acute procedural characteristics and syncope recurrence were compared between groups. Forty\u2010seven consecutive patients with VMB who underwent FE\u2010guided GP ablation were enrolled, <jats:italic>n<\/jats:italic>\u2009=\u200931 in Group 1 and <jats:italic>n<\/jats:italic>\u2009=\u200916 in Group 2. The mean number of ablation points in each GP was comparable between groups. The ratio of positive vagal response during ablation on the left superior GP was higher in Group 1 (90.3% vs. 62.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.022). Ablation of the right superior GP increased heart rate acutely without any vagal response in 45 (95.7%) cases. The procedure time was longer in group 2 (83.4\u2009\u00b1\u200921 vs. 118.0\u2009\u00b1\u200921\u2009min, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Over a mean follow\u2010up duration of 8.0\u2009\u00b1\u20093 months (range 2\u201324 months), none of the patients suffered from syncope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This multi\u2010center pilot study shows for the first time the feasibility of FE\u2010guided GP ablation across a large group of procedure\u2010na\u00efve operators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.15278","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T18:08:52Z","timestamp":1634839732000},"page":"117-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Procedural and short\u2010term results of electroanatomic\u2010mapping\u2010guided ganglionated plexus ablation by first\u2010time operators: A multicenter study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8061-9660","authenticated-orcid":false,"given":"Tolga","family":"Aksu","sequence":"first","affiliation":[{"name":"Department of Cardiology Yeditepe University Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-114X","authenticated-orcid":false,"given":"Tom","family":"De Potter","sequence":"additional","affiliation":[{"name":"Department of Cardiology OLV Hospital Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-2279","authenticated-orcid":false,"given":"Leah","family":"John","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of South Carolina  South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Arrhythmia Institute at Grandview  Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Queen's Medical Center Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Alyesh","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Cardiac Electrophysiology South Denver Cardiology Associates Littleton Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Baysal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gazi Ya\u015fargil Training and Research Hospital Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beth Israel Deaconess Medical Center Boston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Mikaeili","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Day General Hospital Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"dal Forno","sequence":"additional","affiliation":[{"name":"SOS Cardio Hospital Florinapolis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-0711","authenticated-orcid":false,"given":"Kivanc","family":"Yalin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Akdemir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Goztepe Medicalpark Hospital Bahcesehir University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Palo Alto Medical Foundation Mills\u2010Peninsula Medical Center Burlingame California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Palo Alto Medical Foundation Mills\u2010Peninsula Medical Center Burlingame California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Eftekharzadeh","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Day General Hospital Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylan","family":"Akgun","sequence":"additional","affiliation":[{"name":"Basaksehir Cam and Sakura City Hospital Ba\u015fak\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-9745","authenticated-orcid":false,"given":"Sri","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Cardiac Electrophysiology South Denver Cardiology Associates Littleton Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dursun","family":"Aras","sequence":"additional","affiliation":[{"name":"Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8514-1165","authenticated-orcid":false,"given":"Wendy S.","family":"Tzou","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Cardiac Electrophysiology Section University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-3687","authenticated-orcid":false,"given":"Rakesh","family":"Gopinathannair","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kansas City Heart Rhythm Institute and Research Foundation Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Winterfield","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of South Carolina  South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-090X","authenticated-orcid":false,"given":"Dhiraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart and Chest Hospital Liverpool 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